This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4xuj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:31, 8 November 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
==X-ray structure of NCP containing RuII-arene complex of thiomorpholine substituted 3-Hydroxy-2-pyridone ligands==
+
 
-
<StructureSection load='4xuj' size='340' side='right' caption='[[4xuj]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
+
==Nucleosome core particle containing adducts from treatment with a thiomorpholine-substituted [(eta-6-p-cymene)Ru(3-hydroxy-2-pyridone)Cl] compound==
 +
<StructureSection load='4xuj' size='340' side='right'caption='[[4xuj]], [[Resolution|resolution]] 3.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4xuj]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XUJ FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4xuj]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XUJ FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4A6:[(1,2,3,4,5,6-ETA)-1-METHYL-4-(PROPAN-2-YL)BENZENE]RUTHENIUM'>4A6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.18&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuj OCA], [http://pdbe.org/4xuj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xuj RCSB], [http://www.ebi.ac.uk/pdbsum/4xuj PDBsum]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4A6:[(1,2,3,4,5,6-ETA)-1-METHYL-4-(PROPAN-2-YL)BENZENE]RUTHENIUM'>4A6</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xuj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xuj OCA], [https://pdbe.org/4xuj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xuj RCSB], [https://www.ebi.ac.uk/pdbsum/4xuj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xuj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/H2B11_XENLA H2B11_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H32_XENLA H32_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H4_XENLA H4_XENLA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
+
[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
 +
 
 +
==See Also==
 +
*[[Histone 3D structures|Histone 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adhireksan, Z]]
+
[[Category: Large Structures]]
-
[[Category: Davey, C A]]
+
[[Category: Synthetic construct]]
-
[[Category: Dna-bindig protein-dna complex]]
+
[[Category: Xenopus laevis]]
-
[[Category: Dna-binding protein-dna complex]]
+
[[Category: Adhireksan Z]]
-
[[Category: Nucleosome]]
+
[[Category: Davey CA]]
-
[[Category: Ruthenium agent]]
+

Current revision

Nucleosome core particle containing adducts from treatment with a thiomorpholine-substituted [(eta-6-p-cymene)Ru(3-hydroxy-2-pyridone)Cl] compound

PDB ID 4xuj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4xuj"
Personal tools