4zj9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Small heat shock protein AgsA from Salmonella typhimurium: Alpha crystallin domain== | |
| + | <StructureSection load='4zj9' size='340' side='right'caption='[[4zj9]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4zj9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJ9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zj9 OCA], [https://pdbe.org/4zj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zj9 RCSB], [https://www.ebi.ac.uk/pdbsum/4zj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zj9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q8ZPY6_SALTY Q8ZPY6_SALTY] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. Owing to the dynamic nature of small heat shock protein oligomers, elucidating the structural basis of chaperone action and oligomerization still remains a challenge. In order to understand the organization of sHSP oligomers, we have determined crystal structures of a small heat shock protein from Salmonella typhimurium in a dimeric form and two higher oligomeric forms: an 18-mer and a 24-mer. Though the core dimer structure is conserved in all the forms, structural heterogeneity arises due to variation in the terminal regions. | ||
| - | + | Multiple oligomeric structures of a bacterial small heat shock protein.,Mani N, Bhandari S, Moreno R, Hu L, Prasad BV, Suguna K Sci Rep. 2016 Apr 7;6:24019. doi: 10.1038/srep24019. PMID:27053150<ref>PMID:27053150</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Mani | + | <div class="pdbe-citations 4zj9" style="background-color:#fffaf0;"></div> |
| - | [[Category: Suguna | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Salmonella enterica subsp. enterica serovar Typhimurium]] | ||
| + | [[Category: Mani N]] | ||
| + | [[Category: Suguna K]] | ||
Current revision
Small heat shock protein AgsA from Salmonella typhimurium: Alpha crystallin domain
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