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5ax8

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==Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase==
==Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase==
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<StructureSection load='5ax8' size='340' side='right' caption='[[5ax8]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
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<StructureSection load='5ax8' size='340' side='right'caption='[[5ax8]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ax8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AX8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ax8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AX8 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pdb|3pdb]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.989&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ax8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ax8 OCA], [http://pdbe.org/5ax8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ax8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ax8 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ax8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ax8 OCA], [https://pdbe.org/5ax8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ax8 RCSB], [https://www.ebi.ac.uk/pdbsum/5ax8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ax8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AATM_HUMAN AATM_HUMAN]] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.<ref>PMID:9537447</ref>
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[https://www.uniprot.org/uniprot/AATM_HUMAN AATM_HUMAN] Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.<ref>PMID:9537447</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ax8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ax8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aspartate aminotransferase 3D structures|Aspartate aminotransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chang, H]]
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[[Category: Homo sapiens]]
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[[Category: Jiang, X]]
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[[Category: Large Structures]]
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[[Category: Wang, J]]
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[[Category: Chang H]]
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[[Category: Zhou, Y]]
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[[Category: Jiang X]]
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[[Category: Aspartate aminotransferase]]
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[[Category: Wang J]]
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[[Category: Kynurenine aminotransferase-iv]]
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[[Category: Zhou Y]]
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[[Category: Plasma membrane fatty acid binding protein]]
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[[Category: Three-dimensional structure]]
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[[Category: Transferase]]
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Current revision

Recombinant expression, purification and preliminary crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase

PDB ID 5ax8

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