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5ay4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of RNA duplex containing C-C base pairs obtained in the presence of Hg(II)== | |
| + | <StructureSection load='5ay4' size='340' side='right'caption='[[5ay4]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ay4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AY4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AY4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ay4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ay4 OCA], [https://pdbe.org/5ay4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ay4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ay4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ay4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Metallo-base pairs have been extensively studied for applications in nucleic acid-based nanodevices and genetic code expansion. Metallo-base pairs composed of natural nucleobases are attractive because nanodevices containing natural metallo-base pairs can be easily prepared from commercially available sources. Previously, we have reported a crystal structure of a DNA duplex containing THgII T base pairs. Herein, we have determined a high-resolution crystal structure of the second natural metallo-base pair between pyrimidine bases CAgI C formed in an RNA duplex. One AgI occupies the center between two cytosines and forms a CAgI C base pair through N3AgI N3 linear coordination. The CAgI C base pair formation does not disturb the standard A-form conformation of RNA. Since the CAgI C base pair is structurally similar to the canonical Watson-Crick base pairs, it can be a useful building block for structure-based design and fabrication of nucleic acid-based nanodevices. | ||
| - | + | High-Resolution Crystal Structure of Silver(I)-RNA Hybrid Duplex Containing Watson-Crick-like CSilver(I)C Metallo-Base Pairs.,Kondo J, Tada Y, Dairaku T, Saneyoshi H, Okamoto I, Tanaka Y, Ono A Angew Chem Int Ed Engl. 2015 Oct 8. doi: 10.1002/anie.201507894. PMID:26448329<ref>PMID:26448329</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5ay4" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Ono | + | __TOC__ |
| - | [[Category: Saneyoshi | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Tanaka | + | [[Category: Synthetic construct]] |
| + | [[Category: Dairaku T]] | ||
| + | [[Category: Kondo J]] | ||
| + | [[Category: Okamoto I]] | ||
| + | [[Category: Ono A]] | ||
| + | [[Category: Saneyoshi H]] | ||
| + | [[Category: Tada Y]] | ||
| + | [[Category: Tanaka Y]] | ||
Current revision
Crystal structure of RNA duplex containing C-C base pairs obtained in the presence of Hg(II)
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Categories: Large Structures | Synthetic construct | Dairaku T | Kondo J | Okamoto I | Ono A | Saneyoshi H | Tada Y | Tanaka Y
