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5b1l

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==The mouse nucleosome structure containing H3t==
==The mouse nucleosome structure containing H3t==
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<StructureSection load='5b1l' size='340' side='right' caption='[[5b1l]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='5b1l' size='340' side='right'caption='[[5b1l]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5b1l]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B1L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5b1l]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B1L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B1L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5b1m|5b1m]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1l OCA], [http://pdbe.org/5b1l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b1l RCSB], [http://www.ebi.ac.uk/pdbsum/5b1l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b1l OCA], [https://pdbe.org/5b1l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b1l RCSB], [https://www.ebi.ac.uk/pdbsum/5b1l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b1l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/H2B3A_MOUSE H2B3A_MOUSE]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [[http://www.uniprot.org/uniprot/H2A1_MOUSE H2A1_MOUSE]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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[https://www.uniprot.org/uniprot/H4_MOUSE H4_MOUSE]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5b1l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5b1l" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Horikoshi, N]]
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[[Category: Homo sapiens]]
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[[Category: Kurumizaka, H]]
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[[Category: Large Structures]]
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[[Category: Machida, S]]
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[[Category: Mus musculus]]
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[[Category: Osakabe, A]]
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[[Category: Horikoshi N]]
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[[Category: Tachiwana, H]]
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[[Category: Kurumizaka H]]
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[[Category: Taguchi, H]]
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[[Category: Machida S]]
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[[Category: Urahama, T]]
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[[Category: Osakabe A]]
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[[Category: Chromatin]]
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[[Category: Tachiwana H]]
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[[Category: Histone-fold]]
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[[Category: Taguchi H]]
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[[Category: Spermatogenesis]]
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[[Category: Urahama T]]
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[[Category: Structural protein-dna complex]]
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Current revision

The mouse nucleosome structure containing H3t

PDB ID 5b1l

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