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5b4w

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==Crystal structure of Plexin inhibitor complex==
==Crystal structure of Plexin inhibitor complex==
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<StructureSection load='5b4w' size='340' side='right' caption='[[5b4w]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='5b4w' size='340' side='right'caption='[[5b4w]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5b4w]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B4W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5b4w]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B4W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b4w OCA], [http://pdbe.org/5b4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b4w RCSB], [http://www.ebi.ac.uk/pdbsum/5b4w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b4w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b4w OCA], [https://pdbe.org/5b4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b4w RCSB], [https://www.ebi.ac.uk/pdbsum/5b4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b4w ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PLXB1_HUMAN PLXB1_HUMAN]] Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.<ref>PMID:12198496</ref> <ref>PMID:12196628</ref> <ref>PMID:15210733</ref> <ref>PMID:19843518</ref> <ref>PMID:20877282</ref> <ref>PMID:21912513</ref>
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[https://www.uniprot.org/uniprot/PLXB1_HUMAN PLXB1_HUMAN] Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.<ref>PMID:12198496</ref> <ref>PMID:12196628</ref> <ref>PMID:15210733</ref> <ref>PMID:19843518</ref> <ref>PMID:20877282</ref> <ref>PMID:21912513</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5b4w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5b4w" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Plexin 3D structures|Plexin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arimori, T]]
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[[Category: Homo sapiens]]
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[[Category: Kitago, Y]]
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[[Category: Large Structures]]
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[[Category: Matsunaga, Y]]
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[[Category: Unidentified]]
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[[Category: Takagi, J]]
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[[Category: Arimori T]]
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[[Category: Inhibitor]]
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[[Category: Kitago Y]]
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[[Category: Plexin]]
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[[Category: Matsunaga Y]]
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[[Category: Signaling protein]]
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[[Category: Takagi J]]

Current revision

Crystal structure of Plexin inhibitor complex

PDB ID 5b4w

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