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5c3i

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'''Unreleased structure'''
 
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The entry 5c3i is ON HOLD until Paper Publication
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==Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2==
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<StructureSection load='5c3i' size='340' side='right'caption='[[5c3i]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c3i]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C3I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3i OCA], [https://pdbe.org/5c3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c3i RCSB], [https://www.ebi.ac.uk/pdbsum/5c3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3i ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ASF1A_HUMAN ASF1A_HUMAN] Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.<ref>PMID:10759893</ref> <ref>PMID:11897662</ref> <ref>PMID:12842904</ref> <ref>PMID:14718166</ref> <ref>PMID:15621527</ref> <ref>PMID:16151251</ref> <ref>PMID:15664198</ref>
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Authors: Wang, H., Wang, M., Yang, N., Xu, R.M.
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==See Also==
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*[[Anti-silencing factor 3D structures|Anti-silencing factor 3D structures]]
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Description: Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Wang, M]]
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__TOC__
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[[Category: Xu, R.M]]
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</StructureSection>
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[[Category: Yang, N]]
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[[Category: Homo sapiens]]
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[[Category: Wang, H]]
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[[Category: Large Structures]]
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[[Category: Wang H]]
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[[Category: Wang M]]
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[[Category: Xu RM]]
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[[Category: Yang N]]

Current revision

Crystal structure of the quaternary complex of histone H3-H4 heterodimer with chaperone ASF1 and the replicative helicase subunit MCM2

PDB ID 5c3i

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