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2l2z

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==Thiostrepton, reduced at N-CA bond of residue 14==
==Thiostrepton, reduced at N-CA bond of residue 14==
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<StructureSection load='2l2z' size='340' side='right' caption='[[2l2z]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l2z' size='340' side='right'caption='[[2l2z]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L2Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l2z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_azureus Streptomyces azureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2Z FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=QUA:8-HYDROXY-4-(1-HYDROXYETHYL)QUINOLINE-2-CARBOXYLIC+ACID'>QUA</scene>, <scene name='pdbligand=TS9:(2S,3S,4R)-2-AMINO-3,4-DIHYDROXY-3-METHYLPENTANOIC+ACID'>TS9</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e9w|1e9w]], [[2jq7|2jq7]], [[2l2w|2l2w]], [[2l2x|2l2x]], [[2l2y|2l2y]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BB9:(2Z)-2-AMINO-3-SULFANYLPROP-2-ENOIC+ACID'>BB9</scene>, <scene name='pdbligand=DBU:(2Z)-2-AMINOBUT-2-ENOIC+ACID'>DBU</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PRD_000758:THIOPEPTIDE+THIOSTREPTON+REDUCED+AT+N-CA+BOND+OF+RESIDUE+14'>PRD_000758</scene>, <scene name='pdbligand=QUA:8-HYDROXY-4-(1-HYDROXYETHYL)QUINOLINE-2-CARBOXYLIC+ACID'>QUA</scene>, <scene name='pdbligand=TS9:(2S,3S,4R)-2-AMINO-3,4-DIHYDROXY-3-METHYLPENTANOIC+ACID'>TS9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l2z RCSB], [http://www.ebi.ac.uk/pdbsum/2l2z PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2z OCA], [https://pdbe.org/2l2z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2z RCSB], [https://www.ebi.ac.uk/pdbsum/2l2z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2z ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/THCL_STRAJ THCL_STRAJ] Has bacteriocidal activity. Inhibits bacterial protein biosynthesis by acting on the elongation factor Tu (EF-Tu) (By similarity).
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces azureus]]
[[Category: Streptomyces azureus]]
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[[Category: Arndt, H D]]
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[[Category: Arndt H-D]]
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[[Category: Baumann, S]]
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[[Category: Baumann S]]
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[[Category: Hiller, F]]
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[[Category: Hiller F]]
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[[Category: Jonker, H R.A]]
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[[Category: Jonker HRA]]
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[[Category: Kirschner, K N]]
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[[Category: Kirschner KN]]
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[[Category: Schoof, S]]
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[[Category: Schoof S]]
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[[Category: Schulte, K W]]
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[[Category: Schulte KW]]
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[[Category: Schwalbe, H]]
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[[Category: Schwalbe H]]
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[[Category: Wolf, A]]
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[[Category: Wolf A]]
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[[Category: Antibacterial]]
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[[Category: Antibiotic]]
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[[Category: Antimicrobial]]
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[[Category: Natural antibiotic]]
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[[Category: Thiazole]]
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[[Category: Thiazoline]]
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[[Category: Thiopeptide]]
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Current revision

Thiostrepton, reduced at N-CA bond of residue 14

PDB ID 2l2z

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