1o76

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[[Image:1o76.jpg|left|200px]]
[[Image:1o76.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1o76 |SIZE=350|CAPTION= <scene name='initialview01'>1o76</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1o76", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:K+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CAM:CAMPHOR'>CAM</scene>, <scene name='pdbligand=CYN:CYANIDE+ION'>CYN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Camphor_5-monooxygenase Camphor 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.15.1 1.14.15.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1o76| PDB=1o76 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o76 OCA], [http://www.ebi.ac.uk/pdbsum/1o76 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o76 RCSB]</span>
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}}
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'''CYANIDE COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA'''
'''CYANIDE COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA'''
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[[Category: Ghosh, D.]]
[[Category: Ghosh, D.]]
[[Category: Schlichting, I.]]
[[Category: Schlichting, I.]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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[[Category: heme]]
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[[Category: Heme]]
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[[Category: mono-oxygenase]]
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[[Category: Mono-oxygenase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:28:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:40:52 2008''
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Revision as of 00:28, 3 May 2008

Image:1o76.jpg

Template:STRUCTURE 1o76

CYANIDE COMPLEX OF P450CAM FROM PSEUDOMONAS PUTIDA


Overview

The crystal structure of the ternary cyanide complex of P450cam and camphor was determined to 1.8A resolution and found to be identical with the structure of the active oxygen complex [I. Schlichting et al., 2000, Science 287, 1615]. Notably, cyanide binds in a bent mode and induces the active conformation that is characterized by the presence of two water molecules and a flip of the carbonyl of the conserved Asp251. The structure of the ternary complex of cyanide, L-arginine, and the oxygenase domain of inducible nitric oxide synthase was determined to 2.4A resolution. Cyanide binds essentially linearly, interacts with L-Arg, and induces the binding of a water molecule at the active site. This water is positioned by backbone interactions, located 2.8A from the nitrogen atom of cyanide, and could provide a proton required for O-O bond scission in the hydroxylation reaction of nitric oxide synthase.

About this Structure

1O76 is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase-structural models of the short-lived oxygen complexes., Fedorov R, Ghosh DK, Schlichting I, Arch Biochem Biophys. 2003 Jan 1;409(1):25-31. PMID:12464241 Page seeded by OCA on Sat May 3 03:28:09 2008

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