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1o7g

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[[Image:1o7g.jpg|left|200px]]
[[Image:1o7g.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1o7g |SIZE=350|CAPTION= <scene name='initialview01'>1o7g</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1o7g", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Edo+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=NPY:NAPHTHALENE'>NPY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Naphthalene_1,2-dioxygenase Naphthalene 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.12.12 1.14.12.12] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1o7g| PDB=1o7g | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7g OCA], [http://www.ebi.ac.uk/pdbsum/1o7g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o7g RCSB]</span>
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}}
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'''NAPHTHALENE 1,2-DIOXYGENASE WITH NAPHTHALENE BOUND IN THE ACTIVE SITE.'''
'''NAPHTHALENE 1,2-DIOXYGENASE WITH NAPHTHALENE BOUND IN THE ACTIVE SITE.'''
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[[Category: Parales, R E.]]
[[Category: Parales, R E.]]
[[Category: Ramaswamy, S.]]
[[Category: Ramaswamy, S.]]
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[[Category: aromatic hydrocarbon catabolism]]
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[[Category: Aromatic hydrocarbon catabolism]]
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[[Category: enzyme-substrate complex]]
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[[Category: Enzyme-substrate complex]]
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[[Category: iron-sulfur]]
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[[Category: Iron-sulfur]]
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[[Category: non-heme iron dioxygenase]]
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[[Category: Non-heme iron dioxygenase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:28:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:41:00 2008''
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Revision as of 00:28, 3 May 2008

Image:1o7g.jpg

Template:STRUCTURE 1o7g

NAPHTHALENE 1,2-DIOXYGENASE WITH NAPHTHALENE BOUND IN THE ACTIVE SITE.


Overview

Binding of oxygen to iron is exploited in several biological and chemical processes. Although computational and spectroscopic results have suggested side-on binding, only end-on binding of oxygen to iron has been observed in crystal structures. We have determined structures of naphthalene dioxygenase that show a molecular oxygen species bound to the mononuclear iron in a side-on fashion. In a complex with substrate and dioxygen, the dioxygen molecule is lined up for an attack on the double bond of the aromatic substrate. The structures reported here provide the basis for a reaction mechanism and for the high stereospecificity of the reaction catalyzed by naphthalene dioxygenase.

About this Structure

1O7G is a Protein complex structure of sequences from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Crystal structure of naphthalene dioxygenase: side-on binding of dioxygen to iron., Karlsson A, Parales JV, Parales RE, Gibson DT, Eklund H, Ramaswamy S, Science. 2003 Feb 14;299(5609):1039-42. PMID:12586937 Page seeded by OCA on Sat May 3 03:28:49 2008

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