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5n09

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==Crystal structure of L107C/A313C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11==
==Crystal structure of L107C/A313C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11==
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<StructureSection load='5n09' size='340' side='right' caption='[[5n09]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
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<StructureSection load='5n09' size='340' side='right'caption='[[5n09]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n09]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N09 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n09]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N09 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n09 OCA], [http://pdbe.org/5n09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n09 RCSB], [http://www.ebi.ac.uk/pdbsum/5n09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n09 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n09 OCA], [https://pdbe.org/5n09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n09 RCSB], [https://www.ebi.ac.uk/pdbsum/5n09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n09 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C3VXD1_9FLAV C3VXD1_9FLAV]] Peptide 2k: Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[SAAS:SAAS00882589]
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[https://www.uniprot.org/uniprot/A0A0B4SHY9_9FLAV A0A0B4SHY9_9FLAV]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5n09" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5n09" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Dengue virus 2]]
[[Category: Dengue virus 2]]
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Duquerroy, S]]
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[[Category: Large Structures]]
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[[Category: Guardado-Calvo, P]]
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[[Category: Duquerroy S]]
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[[Category: Rey, F]]
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[[Category: Guardado-Calvo P]]
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[[Category: Rouvinski, A]]
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[[Category: Rey F]]
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[[Category: Sharma, A]]
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[[Category: Rouvinski A]]
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[[Category: Vaney, M C]]
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[[Category: Sharma A]]
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[[Category: Broadly neutralizing antibody]]
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[[Category: Vaney M-C]]
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[[Category: Class 2 fusion protein]]
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[[Category: Dengue virus]]
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[[Category: Fab fragment]]
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[[Category: Immune system-viral protein complex]]
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[[Category: Membrane fusion]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of L107C/A313C covalently linked dengue 2 virus envelope glycoprotein dimer in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11

PDB ID 5n09

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