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5n2l
From Proteopedia
(Difference between revisions)
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==Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue== | ==Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue== | ||
| - | <StructureSection load='5n2l' size='340' side='right' caption='[[5n2l]], [[Resolution|resolution]] 1.89Å' scene=''> | + | <StructureSection load='5n2l' size='340' side='right'caption='[[5n2l]], [[Resolution|resolution]] 1.89Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5n2l]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5n2l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N2L FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8J2:propan-2-yl+~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate'>8J2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8J2:propan-2-yl+~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate'>8J2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2l OCA], [https://pdbe.org/5n2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n2l RCSB], [https://www.ebi.ac.uk/pdbsum/5n2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2l ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> |
==See Also== | ==See Also== | ||
| - | *[[Bromodomain-containing protein|Bromodomain-containing protein]] | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bharatham | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bharatham N]] |
| - | [[Category: Boyd | + | [[Category: Bountra C]] |
| - | [[Category: Chai | + | [[Category: Boyd VA]] |
| - | [[Category: Chen | + | [[Category: Chai S]] |
| - | + | [[Category: Chen T]] | |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Fedorov | + | [[Category: Fedorov O]] |
| - | [[Category: Guy | + | [[Category: Guy RK]] |
| - | [[Category: Heroven | + | [[Category: Heroven C]] |
| - | [[Category: Knapp | + | [[Category: Knapp S]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: Lee | + | [[Category: Lee RE]] |
| - | [[Category: Picaud | + | [[Category: Picaud S]] |
| - | + | [[Category: Shadrick WR]] | |
| - | [[Category: Shadrick | + | [[Category: Shelat AA]] |
| - | [[Category: Shelat | + | [[Category: Siejka P]] |
| - | [[Category: Siejka | + | [[Category: Slavish PJ]] |
| - | [[Category: Slavish | + | [[Category: Tallant C]] |
| - | [[Category: Tallant | + | [[Category: Wiggers HJ]] |
| - | [[Category: Wiggers | + | [[Category: Young BM]] |
| - | [[Category: Young | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bharatham N | Bountra C | Boyd VA | Chai S | Chen T | Edwards AM | Fedorov O | Guy RK | Heroven C | Knapp S | Krojer T | Lee RE | Picaud S | Shadrick WR | Shelat AA | Siejka P | Slavish PJ | Tallant C | Wiggers HJ | Young BM | Von Delft F
