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5n2m

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Current revision (17:58, 8 November 2023) (edit) (undo)
 
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<StructureSection load='5n2m' size='340' side='right'caption='[[5n2m]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
<StructureSection load='5n2m' size='340' side='right'caption='[[5n2m]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n2m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5N2M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n2m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N2M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8J2:propan-2-yl+~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate'>8J2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5n2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2m OCA], [http://pdbe.org/5n2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n2m RCSB], [http://www.ebi.ac.uk/pdbsum/5n2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2m ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8J2:propan-2-yl+~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate'>8J2</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n2m OCA], [https://pdbe.org/5n2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n2m RCSB], [https://www.ebi.ac.uk/pdbsum/5n2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n2m ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bharatham, N]]
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[[Category: Bharatham N]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Boyd, V A]]
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[[Category: Boyd VA]]
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[[Category: Chai, S]]
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[[Category: Chai S]]
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[[Category: Chen, T]]
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[[Category: Chen T]]
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[[Category: Delft, F von]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Fedorov O]]
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[[Category: Fedorov, O]]
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[[Category: Guy RK]]
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[[Category: Guy, R K]]
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[[Category: Heroven C]]
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[[Category: Heroven, C]]
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[[Category: Knapp S]]
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[[Category: Knapp, S]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Lee RE]]
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[[Category: Lee, R E]]
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[[Category: Picaud S]]
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[[Category: Picaud, S]]
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[[Category: Shadrick WR]]
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[[Category: Structural genomic]]
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[[Category: Shelat AA]]
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[[Category: Shadrick, W R]]
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[[Category: Siejka P]]
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[[Category: Shelat, A A]]
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[[Category: Slavish PJ]]
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[[Category: Siejka, P]]
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[[Category: Tallant C]]
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[[Category: Slavish, P J]]
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[[Category: Wiggers HJ]]
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[[Category: Tallant, C]]
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[[Category: Young BM]]
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[[Category: Wiggers, H J]]
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[[Category: Von Delft F]]
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[[Category: Young, B M]]
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[[Category: Sgc]]
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[[Category: Transcription]]
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Current revision

Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue

PDB ID 5n2m

Drag the structure with the mouse to rotate

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