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1a7z
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1a7z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a7z, resolution 0.95Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1a7z.jpg|left|200px]]<br /><applet load="1a7z" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1a7z, resolution 0.95Å" /> | ||
| - | '''CRYSTAL STRUCTURE OF ACTINOMYCIN Z3'''<br /> | ||
| - | == | + | ==CRYSTAL STRUCTURE OF ACTINOMYCIN Z3== |
| - | + | <StructureSection load='1a7z' size='340' side='right'caption='[[1a7z]], [[Resolution|resolution]] 0.95Å' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[1a7z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A7Z FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95Å</td></tr> |
| - | [[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BNZ:BENZENE'>BNZ</scene>, <scene name='pdbligand=CTH:4-CHLOROTHREONINE'>CTH</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=H5M:TRANS-3-HYDROXY-5-METHYLPROLINE'>H5M</scene>, <scene name='pdbligand=MAA:N-METHYL-L-ALANINE'>MAA</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=POM:CIS-5-METHYL-4-OXOPROLINE'>POM</scene>, <scene name='pdbligand=PRD_000009:Actinomycin+Z3'>PRD_000009</scene>, <scene name='pdbligand=PXZ:2-AMINO-1,9-DICARBONYL-4,6-DIMETHYL-10-DEHYDRO-PHENOXAZIN-3-ONE'>PXZ</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a7z OCA], [https://pdbe.org/1a7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a7z RCSB], [https://www.ebi.ac.uk/pdbsum/1a7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a7z ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Untwinned single crystals of the actinomycins D and Z3 that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which are present in the form of a hydrogen-bridged dimer related by a pseudo-twofold axis (see picture). | ||
| - | + | Crystal Structures of Actinomycin D and Actinomycin Z3.,Schafer M, Sheldrick GM, Bahner I, Lackner H Angew Chem Int Ed Engl. 1998 Sep 18;37(17):2381-2384. doi:, 10.1002/(SICI)1521-3773(19980918)37:17<2381::AID-ANIE2381>3.0.CO;2-L. PMID:29710967<ref>PMID:29710967</ref> | |
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 1a7z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Streptomyces fradiae]] | ||
| + | [[Category: Schafer M]] | ||
Current revision
CRYSTAL STRUCTURE OF ACTINOMYCIN Z3
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