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2kmj

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{{Seed}}
 
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[[Image:2kmj.jpg|left|200px]]
 
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==High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry==
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The line below this paragraph, containing "STRUCTURE_2kmj", creates the "Structure Box" on the page.
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<StructureSection load='2kmj' size='340' side='right'caption='[[2kmj]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kmj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMJ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZUK:5-PYRIMIDIN-2-YL-D-NORVALINE'>ZUK</scene></td></tr>
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{{STRUCTURE_2kmj| PDB=2kmj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmj OCA], [https://pdbe.org/2kmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmj RCSB], [https://www.ebi.ac.uk/pdbsum/2kmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmj ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge.
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===High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry===
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Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.,Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wohnert J, Gobel M, Schwalbe H Chembiochem. 2009 Jun 15;10(9):1490-4. PMID:19444830<ref>PMID:19444830</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19444830}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kmj" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19444830 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19444830}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2KMJ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA].
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==Reference==
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<ref group="xtra">PMID:19444830</ref><references group="xtra"/>
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[[Category: Human immunodeficiency virus 2]]
[[Category: Human immunodeficiency virus 2]]
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[[Category: Breitung, S.]]
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[[Category: Large Structures]]
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[[Category: Ferner, J.]]
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[[Category: Breitung S]]
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[[Category: Goebel, M.]]
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[[Category: Ferner J]]
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[[Category: Hennig, M.]]
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[[Category: Goebel M]]
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[[Category: Jonker, H R.]]
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[[Category: Hennig M]]
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[[Category: Schwalbe, H.]]
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[[Category: Jonker HRA]]
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[[Category: Suhartono, M.]]
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[[Category: Schwalbe H]]
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[[Category: Woehnert, J.]]
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[[Category: Suhartono M]]
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[[Category: Binding stoichiometry]]
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[[Category: Woehnert J]]
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[[Category: Hiv-2 tar]]
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[[Category: Rna-ligand complex]]
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[[Category: Rna/peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:04:23 2009''
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Current revision

High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry

PDB ID 2kmj

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