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2ldc

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==Solution structure of the estrogen receptor-binding stapled peptide SP1 (Ac-HXILHXLLQDS-NH2)==
==Solution structure of the estrogen receptor-binding stapled peptide SP1 (Ac-HXILHXLLQDS-NH2)==
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<StructureSection load='2ldc' size='340' side='right' caption='[[2ldc]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2ldc' size='340' side='right'caption='[[2ldc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ldc]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LDC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LDC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ldc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LDC FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2lda|2lda]], [[2ldd|2ldd]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=MK8:2-METHYL-L-NORLEUCINE'>MK8</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ldc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ldc OCA], [http://pdbe.org/2ldc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ldc RCSB], [http://www.ebi.ac.uk/pdbsum/2ldc PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ldc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ldc OCA], [https://pdbe.org/2ldc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ldc RCSB], [https://www.ebi.ac.uk/pdbsum/2ldc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ldc ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Note=Chromosomal aberrations involving NCOA2 may be a cause of acute myeloid leukemias. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation.
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== Function ==
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[https://www.uniprot.org/uniprot/NCOA2_HUMAN NCOA2_HUMAN] Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.<ref>PMID:9430642</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bazin, R]]
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[[Category: Homo sapiens]]
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[[Category: Bent, A]]
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[[Category: Large Structures]]
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[[Category: Brown, D]]
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[[Category: Bazin R]]
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[[Category: Davies, N]]
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[[Category: Bent A]]
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[[Category: Irving, S]]
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[[Category: Brown D]]
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[[Category: Moore, R]]
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[[Category: Davies N]]
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[[Category: Pannifer, A]]
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[[Category: Irving S]]
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[[Category: Phillips, C]]
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[[Category: Moore R]]
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[[Category: Pickford, A]]
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[[Category: Pannifer A]]
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[[Category: Prior, S]]
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[[Category: Phillips C]]
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[[Category: Read, C]]
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[[Category: Pickford A]]
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[[Category: Roberts, L]]
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[[Category: Prior S]]
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[[Category: Schade, M]]
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[[Category: Read C]]
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[[Category: Scott, A]]
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[[Category: Roberts L]]
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[[Category: Xu, B]]
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[[Category: Schade M]]
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[[Category: De novo protein]]
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[[Category: Scott A]]
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[[Category: Xu B]]

Current revision

Solution structure of the estrogen receptor-binding stapled peptide SP1 (Ac-HXILHXLLQDS-NH2)

PDB ID 2ldc

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