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5ein

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==Crystal structure of C148A mutant of LysY from Thermus thermophilus in complex with NADP+ and LysW-gamma-aminoadipic acid==
==Crystal structure of C148A mutant of LysY from Thermus thermophilus in complex with NADP+ and LysW-gamma-aminoadipic acid==
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<StructureSection load='5ein' size='340' side='right' caption='[[5ein]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='5ein' size='340' side='right'caption='[[5ein]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ein]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EIN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ein]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] and [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EIN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=UN1:2-AMINOHEXANEDIOIC+ACID'>UN1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eio|5eio]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=R0K:(2~{S})-2-[[(4~{S})-4-azanyl-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]hexanedioic+acid'>R0K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ein OCA], [http://pdbe.org/5ein PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ein RCSB], [http://www.ebi.ac.uk/pdbsum/5ein PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ein FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ein OCA], [https://pdbe.org/5ein PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ein RCSB], [https://www.ebi.ac.uk/pdbsum/5ein PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ein ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARGC2_THET2 ARGC2_THET2]] Involved in both the arginine and lysine biosynthetic pathways.
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[https://www.uniprot.org/uniprot/LYSY_THET2 LYSY_THET2] Catalyzes the NADPH-dependent reduction of [LysW]-aminoadipate 6-phosphate to yield [LysW]-aminoadipate 6-semialdehyde.[HAMAP-Rule:MF_02083]<ref>PMID:26966182</ref> <ref>PMID:19620981</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Nishiyama, M]]
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[[Category: Large Structures]]
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[[Category: Shimizu, T]]
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[[Category: Thermus thermophilus]]
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[[Category: Tomita, T]]
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[[Category: Thermus thermophilus HB27]]
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[[Category: Amino group-carrier-protein]]
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[[Category: Nishiyama M]]
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[[Category: Gapdh family]]
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[[Category: Shimizu T]]
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[[Category: Lysine biosynthesis]]
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[[Category: Tomita T]]
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[[Category: Oxidoreductase-biosynthetic protein complex]]
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Current revision

Crystal structure of C148A mutant of LysY from Thermus thermophilus in complex with NADP+ and LysW-gamma-aminoadipic acid

PDB ID 5ein

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