This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5qgo
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='5qgo' size='340' side='right'caption='[[5qgo]], [[Resolution|resolution]] 1.82Å' scene=''> | <StructureSection load='5qgo' size='340' side='right'caption='[[5qgo]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5qgo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QGO OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5qgo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QGO FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H4A:(3aR,4R,6R,7R,8aR)-6-phenyloctahydro-1H-3a,7-epiminocyclohepta[c]pyrrol-4-ol'>H4A | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H4A:(3aR,4R,6R,7R,8aR)-6-phenyloctahydro-1H-3a,7-epiminocyclohepta[c]pyrrol-4-ol'>H4A</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qgo OCA], [https://pdbe.org/5qgo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qgo RCSB], [https://www.ebi.ac.uk/pdbsum/5qgo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qgo ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Aimon | + | [[Category: Aimon A]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Bradley | + | [[Category: Bradley AR]] |
| - | [[Category: Brandao-Neto | + | [[Category: Brandao-Neto J]] |
| - | [[Category: Brennan | + | [[Category: Brennan PE]] |
| - | [[Category: Collins | + | [[Category: Collins P]] |
| - | [[Category: | + | [[Category: Diaz Saez L]] |
| - | [[Category: Douangamath | + | [[Category: Douangamath A]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Elkins | + | [[Category: Elkins J]] |
| - | [[Category: Fairhead | + | [[Category: Fairhead M]] |
| - | [[Category: Huber | + | [[Category: Huber K]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: London | + | [[Category: London N]] |
| - | [[Category: Nelson | + | [[Category: Nelson A]] |
| - | [[Category: Ruda | + | [[Category: Ruda GF]] |
| - | + | [[Category: Spencer J]] | |
| - | [[Category: Spencer | + | [[Category: Srikannathasan V]] |
| - | [[Category: Srikannathasan | + | [[Category: Szommer T]] |
| - | [[Category: Szommer | + | [[Category: Talon R]] |
| - | [[Category: Talon | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with OX-220
| |||||||||||
Categories: Homo sapiens | Large Structures | Aimon A | Arrowsmith CH | Bountra C | Bradley AR | Brandao-Neto J | Brennan PE | Collins P | Diaz Saez L | Douangamath A | Edwards A | Elkins J | Fairhead M | Huber K | Krojer T | London N | Nelson A | Ruda GF | Spencer J | Srikannathasan V | Szommer T | Talon R | Von Delft F
