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5qhf
From Proteopedia
(Difference between revisions)
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<StructureSection load='5qhf' size='340' side='right'caption='[[5qhf]], [[Resolution|resolution]] 1.67Å' scene=''> | <StructureSection load='5qhf' size='340' side='right'caption='[[5qhf]], [[Resolution|resolution]] 1.67Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5qhf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QHF OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5qhf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QHF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QHF FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H1G:2-(4-methoxyphenyl)-N-{5-[2-oxo-2-(3-oxopiperazin-1-yl)ethoxy]pyridin-3-yl}acetamide'>H1G | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=H1G:2-(4-methoxyphenyl)-N-{5-[2-oxo-2-(3-oxopiperazin-1-yl)ethoxy]pyridin-3-yl}acetamide'>H1G</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qhf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qhf OCA], [https://pdbe.org/5qhf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qhf RCSB], [https://www.ebi.ac.uk/pdbsum/5qhf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qhf ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/NUDT7_HUMAN NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Aimon | + | [[Category: Aimon A]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Bradley | + | [[Category: Bradley AR]] |
| - | [[Category: Brandao-Neto | + | [[Category: Brandao-Neto J]] |
| - | [[Category: Brennan | + | [[Category: Brennan PE]] |
| - | [[Category: Collins | + | [[Category: Collins P]] |
| - | [[Category: | + | [[Category: Diaz Saez L]] |
| - | [[Category: Douangamath | + | [[Category: Douangamath A]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Elkins | + | [[Category: Elkins J]] |
| - | [[Category: Fairhead | + | [[Category: Fairhead M]] |
| - | [[Category: Huber | + | [[Category: Huber K]] |
| - | [[Category: Krojer | + | [[Category: Krojer T]] |
| - | [[Category: London | + | [[Category: London N]] |
| - | [[Category: Nelson | + | [[Category: Nelson A]] |
| - | [[Category: Ruda | + | [[Category: Ruda GF]] |
| - | + | [[Category: Spencer J]] | |
| - | [[Category: Spencer | + | [[Category: Srikannathasan V]] |
| - | [[Category: Srikannathasan | + | [[Category: Szommer T]] |
| - | [[Category: Szommer | + | [[Category: Talon R]] |
| - | [[Category: Talon | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with NUOOA000301a
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Categories: Homo sapiens | Large Structures | Aimon A | Arrowsmith CH | Bountra C | Bradley AR | Brandao-Neto J | Brennan PE | Collins P | Diaz Saez L | Douangamath A | Edwards A | Elkins J | Fairhead M | Huber K | Krojer T | London N | Nelson A | Ruda GF | Spencer J | Srikannathasan V | Szommer T | Talon R | Von Delft F
