This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


8emr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "8emr" [edit=sysop:move=sysop])
Current revision (11:33, 15 November 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8emr is ON HOLD until Paper Publication
+
==Cryo-EM structure of human liver glucosidase II==
-
 
+
<StructureSection load='8emr' size='340' side='right'caption='[[8emr]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
-
Authors: Su, C., Lyu, M., Zhang, Z., Yu, E.W.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8emr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EMR FirstGlance]. <br>
-
Description: Cryo-EM structure of human liver glucosidase II
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.92&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
[[Category: Zhang, Z]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8emr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8emr OCA], [https://pdbe.org/8emr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8emr RCSB], [https://www.ebi.ac.uk/pdbsum/8emr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8emr ProSAT]</span></td></tr>
-
[[Category: Su, C]]
+
</table>
-
[[Category: Yu, E.W]]
+
== Disease ==
-
[[Category: Lyu, M]]
+
[https://www.uniprot.org/uniprot/GANAB_HUMAN GANAB_HUMAN] Autosomal dominant polycystic kidney disease. The disease is caused by variants affecting the gene represented in this entry. GANAB variations may act as a disease modifier in autosomal dominant polycystic liver disease in patients who have causative mutations in other genes, such as PKHD1 or ALG8.<ref>PMID:28375157</ref> <ref>PMID:33097077</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GANAB_HUMAN GANAB_HUMAN] Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053).<ref>PMID:10929008</ref> <ref>PMID:27259053</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Lyu M]]
 +
[[Category: Su C]]
 +
[[Category: Yu EW]]
 +
[[Category: Zhang Z]]

Current revision

Cryo-EM structure of human liver glucosidase II

PDB ID 8emr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8emr"
Personal tools