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2l77
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2l77 is ON HOLD Authors: Nanga, R., Brender, J.R., Popovych, N., Ramamoorthy, A. Description: Solution NMR structure of PAP248-286 in 50% TFE ''Pa...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution NMR structure of PAP248-286 in 50% TFE== | |
| + | <StructureSection load='2l77' size='340' side='right'caption='[[2l77]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2l77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L77 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l77 OCA], [https://pdbe.org/2l77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l77 RCSB], [https://www.ebi.ac.uk/pdbsum/2l77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l77 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brender JR]] | ||
| + | [[Category: Nanga R]] | ||
| + | [[Category: Popovych N]] | ||
| + | [[Category: Ramamoorthy A]] | ||
Current revision
Solution NMR structure of PAP248-286 in 50% TFE
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