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2lo7

From Proteopedia

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[[Image:2lo7.png|left|200px]]
 
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==Ts16 NMR solution structure==
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The line below this paragraph, containing "STRUCTURE_2lo7", creates the "Structure Box" on the page.
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<StructureSection load='2lo7' size='340' side='right'caption='[[2lo7]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2lo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tityus_serrulatus Tityus serrulatus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2lka 2lka]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LO7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lo7 OCA], [https://pdbe.org/2lo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2lo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lo7 ProSAT]</span></td></tr>
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{{STRUCTURE_2lo7| PDB=2lo7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KA20_TITSE KA20_TITSE] Blocks potassium channels.[UniProtKB:P0C183]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Scorpion venoms are a rich source of K(+) channel-blocking peptides. For the most part, they are structurally related small disulfide-rich proteins containing a conserved pattern of six cysteines that is assumed to dictate their common three-dimensional folding. In the conventional pattern, two disulfide bridges connect an alpha-helical segment to the C-terminal strand of a double- or triple-stranded beta-sheet, conforming a cystine-stabilized alpha/beta scaffold (CSalpha/beta). Here we show that two K(+) channel-blocking peptides from Tityus scorpions conserve the cysteine spacing of common scorpion venom peptides but display an unconventional disulfide pattern, accompanied by a complete rearrangement of the secondary structure topology into a CS helix-loop-helix fold. Sequence and structural comparisons of the peptides adopting this novel fold suggest that it would be a new elaboration of the widespread CSalpha/beta scaffold, thus revealing an unexpected structural versatility of these small disulfide-rich proteins. Acknowledgment of such versatility is important to understand how venom structural complexity emerged on a limited number of molecular scaffolds.
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===Ts16 NMR solution structure===
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New Tricks of an Old Pattern: STRUCTURAL VERSATILITY OF SCORPION TOXINS WITH COMMON CYSTEINE SPACING.,Saucedo AL, Flores-Solis D, Rodriguez de la Vega RC, Ramirez-Cordero B, Hernandez-Lopez R, Cano-Sanchez P, Navarro RN, Garcia-Valdes J, Coronas-Valderrama F, de Roodt A, Brieba LG, Possani LD, Del Rio-Portilla F J Biol Chem. 2012 Apr 6;287(15):12321-30. Epub 2012 Jan 10. PMID:22238341<ref>PMID:22238341</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22238341}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2lo7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22238341 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22238341}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[2lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tityus_serrulatus Tityus serrulatus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2lka 2lka]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO7 OCA].
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==Reference==
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<ref group="xtra">PMID:022238341</ref><references group="xtra"/>
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[[Category: Tityus serrulatus]]
[[Category: Tityus serrulatus]]
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[[Category: Flores-Solis, D.]]
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[[Category: Flores-Solis D]]
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[[Category: Rio-Portilla, F del.]]
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[[Category: Saucedo AL]]
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[[Category: Saucedo, A L.]]
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[[Category: Del Rio-Portilla F]]
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[[Category: Alpha scorpion toxin]]
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[[Category: Cs alpha alpha motif]]
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[[Category: Toxin]]
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[[Category: Voltage gated potassium channel]]
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Current revision

Ts16 NMR solution structure

PDB ID 2lo7

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