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2lo7

From Proteopedia

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Current revision

Ts16 NMR solution structure

Structural highlights

2lo7 is a 1 chain structure with sequence from Tityus serrulatus. This structure supersedes the now removed PDB entry 2lka. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KA20_TITSE Blocks potassium channels.[UniProtKB:P0C183]

Publication Abstract from PubMed

Scorpion venoms are a rich source of K(+) channel-blocking peptides. For the most part, they are structurally related small disulfide-rich proteins containing a conserved pattern of six cysteines that is assumed to dictate their common three-dimensional folding. In the conventional pattern, two disulfide bridges connect an alpha-helical segment to the C-terminal strand of a double- or triple-stranded beta-sheet, conforming a cystine-stabilized alpha/beta scaffold (CSalpha/beta). Here we show that two K(+) channel-blocking peptides from Tityus scorpions conserve the cysteine spacing of common scorpion venom peptides but display an unconventional disulfide pattern, accompanied by a complete rearrangement of the secondary structure topology into a CS helix-loop-helix fold. Sequence and structural comparisons of the peptides adopting this novel fold suggest that it would be a new elaboration of the widespread CSalpha/beta scaffold, thus revealing an unexpected structural versatility of these small disulfide-rich proteins. Acknowledgment of such versatility is important to understand how venom structural complexity emerged on a limited number of molecular scaffolds.

New Tricks of an Old Pattern: STRUCTURAL VERSATILITY OF SCORPION TOXINS WITH COMMON CYSTEINE SPACING.,Saucedo AL, Flores-Solis D, Rodriguez de la Vega RC, Ramirez-Cordero B, Hernandez-Lopez R, Cano-Sanchez P, Navarro RN, Garcia-Valdes J, Coronas-Valderrama F, de Roodt A, Brieba LG, Possani LD, Del Rio-Portilla F J Biol Chem. 2012 Apr 6;287(15):12321-30. Epub 2012 Jan 10. PMID:22238341^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Saucedo AL, Flores-Solis D, Rodriguez de la Vega RC, Ramirez-Cordero B, Hernandez-Lopez R, Cano-Sanchez P, Navarro RN, Garcia-Valdes J, Coronas-Valderrama F, de Roodt A, Brieba LG, Possani LD, Del Rio-Portilla F. New Tricks of an Old Pattern: STRUCTURAL VERSATILITY OF SCORPION TOXINS WITH COMMON CYSTEINE SPACING. J Biol Chem. 2012 Apr 6;287(15):12321-30. Epub 2012 Jan 10. PMID:22238341 doi:10.1074/jbc.M111.329607

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2lo7"

Categories: Large Structures | Tityus serrulatus | Flores-Solis D | Saucedo AL | Del Rio-Portilla F

@@ Line 1: / Line 1: @@
 ==Ts16 NMR solution structure==
-<StructureSection load='2lo7' size='340' side='right' caption='[[2lo7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2lo7' size='340' side='right'caption='[[2lo7]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2lo7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Brazilian_scorpion Brazilian scorpion]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2lka 2lka]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LO7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2lo7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tityus_serrulatus Tityus serrulatus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2lka 2lka]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LO7 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lo7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lo7 RCSB], [http://www.ebi.ac.uk/pdbsum/2lo7 PDBsum]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lo7 OCA], [https://pdbe.org/2lo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lo7 RCSB], [https://www.ebi.ac.uk/pdbsum/2lo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lo7 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/TTX16_TITSE TTX16_TITSE]] Blocks potassium channels (By similarity).[UniProtKB:P0C183]
+[https://www.uniprot.org/uniprot/KA20_TITSE KA20_TITSE] Blocks potassium channels.[UniProtKB:P0C183]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 15: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2lo7" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Brazilian scorpion]]
+[[Category: Large Structures]]
-[[Category: Flores-Solis, D]]
+[[Category: Tityus serrulatus]]
-[[Category: Rio-Portilla, F del]]
+[[Category: Flores-Solis D]]
-[[Category: Saucedo, A L]]
+[[Category: Saucedo AL]]
-[[Category: Alpha scorpion toxin]]
+[[Category: Del Rio-Portilla F]]
-[[Category: Cs alpha alpha motif]]
-[[Category: Toxin]]
-[[Category: Voltage gated potassium channel]]

2lo7

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Current revision

Ts16 NMR solution structure

Structural highlights

Function

Publication Abstract from PubMed

References

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