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5n7e

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Current revision (12:31, 15 November 2023) (edit) (undo)
 
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<StructureSection load='5n7e' size='340' side='right'caption='[[5n7e]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
<StructureSection load='5n7e' size='340' side='right'caption='[[5n7e]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n7e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N7E OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5N7E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n7e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N7E FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.647&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5n7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n7e OCA], [http://pdbe.org/5n7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n7e RCSB], [http://www.ebi.ac.uk/pdbsum/5n7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n7e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n7e OCA], [https://pdbe.org/5n7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n7e RCSB], [https://www.ebi.ac.uk/pdbsum/5n7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n7e ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BCR_HUMAN BCR_HUMAN]] Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
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[https://www.uniprot.org/uniprot/BCR_HUMAN BCR_HUMAN] Note=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia. Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BCR_HUMAN BCR_HUMAN]] GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.<ref>PMID:1903516</ref> <ref>PMID:1657398</ref>
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[https://www.uniprot.org/uniprot/BCR_HUMAN BCR_HUMAN] GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase activity.<ref>PMID:1903516</ref> <ref>PMID:1657398</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Synthetic construct]]
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[[Category: Hantschel, O]]
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[[Category: Hantschel O]]
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[[Category: Pojer, F]]
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[[Category: Pojer F]]
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[[Category: Reckel, S]]
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[[Category: Reckel S]]
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[[Category: Reynaud, A]]
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[[Category: Reynaud A]]
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[[Category: Bcr-abl]]
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[[Category: Dbl-homology]]
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[[Category: Monobody]]
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[[Category: Signaling protein]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Dbl-homology domain of Bcr-Abl in complex with monobody Mb(Bcr-DH_4).

PDB ID 5n7e

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