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5n8v

From Proteopedia

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Current revision (12:36, 15 November 2023) (edit) (undo)
 
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<StructureSection load='5n8v' size='340' side='right'caption='[[5n8v]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='5n8v' size='340' side='right'caption='[[5n8v]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5N8V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n8v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N8V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KZZ:1-(2-AZANYLETHYL)-5-[(4-METHOXYNAPHTHALEN-1-YL)METHYL]-~{N}-(NAPHTHALEN-1-YLMETHYL)-6,7-DIHYDRO-4~{H}-PYRAZOLO[4,3-C]PYRIDINE-3-CARBOXAMIDE'>KZZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5l8a|5l8a]], [[5l87|5l87]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=KZZ:1-(2-AZANYLETHYL)-5-[(4-METHOXYNAPHTHALEN-1-YL)METHYL]-~{N}-(NAPHTHALEN-1-YLMETHYL)-6,7-DIHYDRO-4~{H}-PYRAZOLO[4,3-C]PYRIDINE-3-CARBOXAMIDE'>KZZ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PEX14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8v OCA], [https://pdbe.org/5n8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n8v RCSB], [https://www.ebi.ac.uk/pdbsum/5n8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8v ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5n8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n8v OCA], [http://pdbe.org/5n8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n8v RCSB], [http://www.ebi.ac.uk/pdbsum/5n8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n8v ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8IEW2_TRYBB Q8IEW2_TRYBB]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trybb]]
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[[Category: Trypanosoma brucei brucei]]
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[[Category: Dawidowski, M]]
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[[Category: Dawidowski M]]
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[[Category: Emmanouilidis, L]]
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[[Category: Emmanouilidis L]]
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[[Category: Popowicz, G M]]
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[[Category: Popowicz GM]]
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[[Category: Sattler, M]]
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[[Category: Sattler M]]
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[[Category: Glycosome]]
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[[Category: Inhibitor]]
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[[Category: Protein-protein interaction inhibitor]]
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[[Category: Signaling protein]]
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[[Category: Structure-based drug discovery]]
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[[Category: Trypanosomiasis]]
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Current revision

Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.

PDB ID 5n8v

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