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5n92

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==Crystal Structure of Human IL-17AF==
==Crystal Structure of Human IL-17AF==
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<StructureSection load='5n92' size='340' side='right' caption='[[5n92]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='5n92' size='340' side='right'caption='[[5n92]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n92]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N92 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n92]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N92 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N92 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n92 OCA], [http://pdbe.org/5n92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n92 RCSB], [http://www.ebi.ac.uk/pdbsum/5n92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n92 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n92 OCA], [https://pdbe.org/5n92 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n92 RCSB], [https://www.ebi.ac.uk/pdbsum/5n92 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n92 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN]] Defects in IL17F are the cause of familial candidiasis type 6 (CANDF6) [MIM:[http://omim.org/entry/613956 613956]]. CANDF6 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.<ref>PMID:21350122</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN]] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. [[http://www.uniprot.org/uniprot/IL17F_HUMAN IL17F_HUMAN]] Stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony-stimulating factor, and can regulate cartilage matrix turnover. Stimulates PBMC and T-cell proliferation. Inhibits angiogenesis.
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[https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5n92" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5n92" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Goepfert, A]]
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[[Category: Homo sapiens]]
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[[Category: Rondeau, J M]]
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[[Category: Large Structures]]
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[[Category: Cystine-knot]]
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[[Category: Goepfert A]]
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[[Category: Heterodimer]]
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[[Category: Rondeau J-M]]
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[[Category: Immune system]]
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Current revision

Crystal Structure of Human IL-17AF

PDB ID 5n92

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