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5nal

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Current revision (12:43, 15 November 2023) (edit) (undo)
 
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<StructureSection load='5nal' size='340' side='right'caption='[[5nal]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='5nal' size='340' side='right'caption='[[5nal]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nal]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NAL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NAL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nal]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NAL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8RQ:~{N}4-[(4-CHLOROPHENYL)METHYL]-~{N}1-(CYCLOHEXYLMETHYL)-~{N}4-CYCLOPENTYL-~{N}1-[(~{Z})-4-[(~{E})-METHYLIMINOMETHYL]-5-OXIDANYL-HEX-4-ENYL]BENZENE-1,4-DISULFONAMIDE'>8RQ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nal OCA], [http://pdbe.org/5nal PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nal RCSB], [http://www.ebi.ac.uk/pdbsum/5nal PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nal ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8RQ:~{N}4-[(4-CHLOROPHENYL)METHYL]-~{N}1-(CYCLOHEXYLMETHYL)-~{N}4-CYCLOPENTYL-~{N}1-[(~{Z})-4-[(~{E})-METHYLIMINOMETHYL]-5-OXIDANYL-HEX-4-ENYL]BENZENE-1,4-DISULFONAMIDE'>8RQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nal OCA], [https://pdbe.org/5nal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nal RCSB], [https://www.ebi.ac.uk/pdbsum/5nal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nal ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
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[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fansa, E K]]
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[[Category: Fansa EK]]
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[[Category: Martin-Gago, P]]
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[[Category: Martin-Gago P]]
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[[Category: Waldmann, H]]
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[[Category: Waldmann H]]
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[[Category: Wittinghofer, A]]
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[[Category: Wittinghofer A]]
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[[Category: Arl2 mediated cargo release]]
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[[Category: Covalent protein labeling at glutamic acid]]
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[[Category: Lipid binding protein]]
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[[Category: Woodward's reagent k]]
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Current revision

The crystal structure of inhibitor-15 covalently bound to PDE6D

PDB ID 5nal

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