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5nd3

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==Microtubule-bound MKLP2 motor domain in the with no nucleotide==
==Microtubule-bound MKLP2 motor domain in the with no nucleotide==
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<StructureSection load='5nd3' size='340' side='right' caption='[[5nd3]], [[Resolution|resolution]] 6.10&Aring;' scene=''>
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<SX load='5nd3' size='340' side='right' viewer='molstar' caption='[[5nd3]], [[Resolution|resolution]] 6.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nd3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ND3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ND3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nd3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ND3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ND3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nd3 OCA], [http://pdbe.org/5nd3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nd3 RCSB], [http://www.ebi.ac.uk/pdbsum/5nd3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nd3 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TA1:TAXOL'>TA1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nd3 OCA], [https://pdbe.org/5nd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nd3 RCSB], [https://www.ebi.ac.uk/pdbsum/5nd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nd3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KI20A_MOUSE KI20A_MOUSE]] Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.<ref>PMID:9438855</ref> [[http://www.uniprot.org/uniprot/TBB2B_BOVIN TBB2B_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). [[http://www.uniprot.org/uniprot/F2Z4C1_BOVIN F2Z4C1_BOVIN]] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.[RuleBase:RU000352][SAAS:SAAS00824325]
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[https://www.uniprot.org/uniprot/KI20A_MOUSE KI20A_MOUSE] Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.<ref>PMID:9438855</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5nd3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5nd3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Kinesin 3D Structures|Kinesin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Atherton, J]]
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[[Category: Large Structures]]
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[[Category: Clause, J]]
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[[Category: Mus musculus]]
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[[Category: Cook, A]]
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[[Category: Atherton J]]
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[[Category: Houdusse, A]]
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[[Category: Clause J]]
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[[Category: Joseph, A P]]
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[[Category: Cook A]]
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[[Category: Major, J]]
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[[Category: Houdusse A]]
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[[Category: Moores, C A]]
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[[Category: Joseph AP]]
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[[Category: Muretta, J M]]
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[[Category: Major J]]
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[[Category: Rosenfeld, S S]]
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[[Category: Moores CA]]
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[[Category: Sourigues, Y]]
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[[Category: Muretta JM]]
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[[Category: Topf, M]]
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[[Category: Rosenfeld SS]]
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[[Category: Yu, I M]]
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[[Category: Sourigues Y]]
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[[Category: Kinesin mitosis microtubule]]
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[[Category: Topf M]]
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[[Category: Motor protein]]
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[[Category: Yu IM]]

Current revision

Microtubule-bound MKLP2 motor domain in the with no nucleotide

5nd3, resolution 6.10Å

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