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ABC transporter 3D structures

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Current revision (08:55, 19 November 2023) (edit) (undo)
 
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Line 56: Line 56:
***[[3dhx]] - EcABC methionine transporter C2 domain<br />
***[[3dhx]] - EcABC methionine transporter C2 domain<br />
***[[2qrr]] - ABC methionine transporter soluble domain - ''Vibrio parahaemolyticus'' <br />
***[[2qrr]] - ABC methionine transporter soluble domain - ''Vibrio parahaemolyticus'' <br />
 +
**[[7mc0]] - NmABC methionine transporter – ''Neisseria meningitides'' – Cryo EM<br />
 +
**[[7mbz]] - NmABC methionine transporter + lipoprotein – Cryo EM<br />
**Alanine ABC transporter
**Alanine ABC transporter
Line 81: Line 83:
***[[3o6p]] - EfABC amino acids transporter<br />
***[[3o6p]] - EfABC amino acids transporter<br />
***[[3ip9]] – AtABC amino acid transporter+GABA<br />
***[[3ip9]] – AtABC amino acid transporter+GABA<br />
 +
***[[7n5a]], [[7n5b]] - AtABC amino acid transporter family 25 + ADP – Cryo EM <br />
 +
***[[7n59]] - AtABC amino acid transporter family 25 + glutathione – Cryo EM <br />
***[[4z9n]] - ABC amino acid transporter+ glutathione – ''Brucella ovis''<br />
***[[4z9n]] - ABC amino acid transporter+ glutathione – ''Brucella ovis''<br />
***[[6gpm]], [[6gpd]] - TmABC amino acid transporter <br />
***[[6gpm]], [[6gpd]] - TmABC amino acid transporter <br />
Line 141: Line 145:
* ABC sugar transporters
* ABC sugar transporters
-
**[[6tha]] - ABC glucose transporter - human <br />
+
**[[6tha]] - hABC glucose transporter - human <br />
 +
**[[4pyp]] - hABC glucose transporter (mutant) <br />
**[[4ybq]] - ABC glucose transporter - rat<br />
**[[4ybq]] - ABC glucose transporter - rat<br />
**[[5ctg]], [[5cth]] - ABC sugar transporter - rice<br />
**[[5ctg]], [[5cth]] - ABC sugar transporter - rice<br />
Line 167: Line 172:
**[[3l49]] - RsABC ribose transporter – ''Rhodobacter sphaeroides''<br />
**[[3l49]] - RsABC ribose transporter – ''Rhodobacter sphaeroides''<br />
**[[4joq]] - RsABC ribose transporter (mutant) <br />
**[[4joq]] - RsABC ribose transporter (mutant) <br />
 +
**[[7e7m]] - ABC ribose transporter + ribose – ''Streptococcus agalactiae'' <br />
 +
**[[7qsq]] - TmABC ribose transporter N-terminal<br />
 +
**[[7qsp]] - TmABC ribose transporter C-terminal<br />
**[[3rot]] - ABC sugar transporter – ''Legionella pneumophila''<br />
**[[3rot]] - ABC sugar transporter – ''Legionella pneumophila''<br />
**[[4kvf]] - ABC rhamnose transporter – ''Kribbella flavida''<br />
**[[4kvf]] - ABC rhamnose transporter – ''Kribbella flavida''<br />
Line 178: Line 186:
**[[7cae]], [[7caf]] – MsABC sugar transporter + LPQY – Cryo EM<br />
**[[7cae]], [[7caf]] – MsABC sugar transporter + LPQY – Cryo EM<br />
**[[7cag]] – MsABC sugar transporter + LPQY + ATP – Cryo EM<br />
**[[7cag]] – MsABC sugar transporter + LPQY + ATP – Cryo EM<br />
 +
**[[7c63]], [[7c69]] - TtABC sugar transporter <br />
 +
**[[7c6f]], [[7c6m]], [[7c6x]], [[7c6y]], [[7c6z]], [[7c1b]], [[7c70]], [[7c71]] - TtABC sugar transporter (mutant)<br />
 +
**[[7c0f]], [[7c0k]], [[7c0l]] - TtABC sugar transporter + UPG<br />
 +
**[[7c0o]], [[7c0r]], [[7c0s]], [[7c0t]], [[7c0u]], [[7c0v]], [[7c0w]], [[7c0x]], [[7c0y]], [[7c0z]], [[7c14]], [[7c15]], [[7c16]], [[7c19]] - TtABC sugar transporter (mutant) + UPG<br />
 +
**[[7c64]], [[7c66]], [[7c67]], [[7c68]] - TtABC sugar transporter + saccharide<br />
 +
**[[[7c6g]], [[7c6h]], [7c6i]], [[7c6j]], [[7c6k]], [[7c6l]], [[7c6n]], [[7c6r]], [[7c6t]], [[7c6v]], [[7c6w]], [[7c70]] - TtABC sugar transporter (mutant) + saccharide<br />
*ABC maltose transporter see [[Maltose-binding protein]]
*ABC maltose transporter see [[Maltose-binding protein]]
Line 222: Line 236:
***[[4h59]], [[4hmo]], [[4hmp]], [[4jcc]] - SpABC iron transporter <br />
***[[4h59]], [[4hmo]], [[4hmp]], [[4jcc]] - SpABC iron transporter <br />
***[[4hmq]] - SpABC iron transporter + ferrichrome<br />
***[[4hmq]] - SpABC iron transporter + ferrichrome<br />
-
***[[3waf]], [[4elo]], [[4elp]], [[4elq]] - TtABC iron transporter <br />
+
***[[3waf]], [[4elo]], [[4elp]], [[4elq]], [[7f6e]], [[7f6f]], [[7f6k]], [[7f6q]], [[7f6u]] - TtABC iron transporter <br />
 +
***[[7f6n]], [[7f6o]], [[7f6p]], [[7f6r]], [[7f6s]], [[7f6t]] - TtABC iron transporter (mutant)<br />
***[[3wae]], [[4elr]] - TtABC iron transporter + Fe<br />
***[[3wae]], [[4elr]] - TtABC iron transporter + Fe<br />
***[[6j2s]] - ABC iron transporter + Ga – ''Pseudomonas aeruginosa''<br />
***[[6j2s]] - ABC iron transporter + Ga – ''Pseudomonas aeruginosa''<br />
***[[5jj5]] - SaABC iron transporter + Fe<br />
***[[5jj5]] - SaABC iron transporter + Fe<br />
 +
***[[7li1]] - ABC iron transporter + Fe – ''Moraxella catarrhalis''<br />
 +
 +
** ABC manganese transporters
 +
 +
***[[7kyp]] - SpABC manganese transporter <br />
 +
***[[7kyo]] - SpABC manganese transporter + antibody<br />
** ABC molybdenum transporters or ModA
** ABC molybdenum transporters or ModA
Line 248: Line 269:
***[[6nio]] - ABC molybdate transporter – ''Yersinia pestis''<br />
***[[6nio]] - ABC molybdate transporter – ''Yersinia pestis''<br />
***[[1atg]] - ABC molybdate transporter + Mo – ''Azotobacter vinelandii''<br />
***[[1atg]] - ABC molybdate transporter + Mo – ''Azotobacter vinelandii''<br />
 +
***[[7tav]] - ABC molybdate transporter – ''Listeria monocytogenes''<br />
** ABC zinc transporters
** ABC zinc transporters
Line 260: Line 282:
* ABC multidrug transporters
* ABC multidrug transporters
 +
**[[6ffc]] – hABCG2 multidrug transporter + inhibitor – Cryo EM<br />
 +
**[[5nj3]] – hABCG2 multidrug transporter (mutant) + antibody – Cryo EM<br />
 +
**[[6hbu]] – hABCG2 multidrug transporter (mutant) + ATP – Cryo EM<br />
 +
**[[6hco]] – hABCG2 multidrug transporter (mutant) + antibody + estrone sulfate – Cryo EM<br />
 +
**[[7p03]], [[7p05]], [[7p04]], [[7p06]] - yABC multidrug transporter + ATP + ADP – Cryo EM<br />
**[[2onj]] - SaABC multidrug transporter+AMP-PNP<br />
**[[2onj]] - SaABC multidrug transporter+AMP-PNP<br />
**[[2hyd]] - SaABC multidrug transporter<br />
**[[2hyd]] - SaABC multidrug transporter<br />
-
**[[1mv5]] - LlABC multidrug transporter ATP binding domain
+
**[[1mv5]] - LlABC multidrug transporter ATP binding domain <brt />
 +
**[[5mkk]] - TtABC multidrug transporter ATP binding domain <br />
 +
**[[6ran]] - TtABC multidrug transporter ATP binding domain + nanobody – Cryo EM<br />
 +
**[[6rag]], [[6rah]], [[6rai]], [[6raj]], [[6rak]], [[6ral]], [[6ram]] - TtABC multidrug transporter ATP binding domain + nanobody + ATP – Cryo EM<br />
 +
**[[6raf]] - TtABC multidrug transporter ATP binding domain + VHH + ATP + ADP – Cryo EM<br />
 +
**[[7ow8]] - BsABC multidrug transporter ATP binding domain + ATP – Cryo EM<br />
 +
**[[7bg4]] - BsABC multidrug transporter ATP binding domain + rhodamine + ATP – Cryo EM<br />
-
* ABC choline transporters
+
* ABC choline transporters or Glycine etaine/carnitine/choline ABC transporters
**[[3hcq]] - SmABC choline transporter (mutant) – ''Sinorhizobium meliloti''<br />
**[[3hcq]] - SmABC choline transporter (mutant) – ''Sinorhizobium meliloti''<br />
Line 270: Line 303:
**[[2reg]] - SmABC choline transporter (mutant)+choline<br />
**[[2reg]] - SmABC choline transporter (mutant)+choline<br />
**[[2rej]], [[2rf1]] - SmABC choline transporter (mutant)<br />
**[[2rej]], [[2rf1]] - SmABC choline transporter (mutant)<br />
-
**[[3o66]] – SaABC choline transporter
+
**[[3o66]] – SaABC choline transporter<br />
 +
**[[3chg]], [[3ppn]], [[3ppo]], [[3ppp]], [[3ppr]] - BsABC OpuAC choline transporter <br />
 +
**[[3ppq]], [[3r6u]] - BsABC OpuBC choline transporter + choline<br />
 +
**[[6eyq]] - BsABC OpuBC choline transporter (mutant) + choline<br />
 +
**[[5nxx]] - BsABC OpuAC choline transporter + arsenobetaine<br />
 +
**[[2b4l]], [[6eyh]] - BsABC OpuAC choline transporter + glycine betaine<br />
 +
**[[2b4m]] - BsABC OpuAC choline transporter + proline betaine<br />
 +
**[[3l6g]], [[3l6h]] – LlABC OpuAC betaine transporter SBD<br />
-
* ABC α-hemolysin transporters
+
* ABC α-hemolysin transporters or alpha-hemolysin translocation ATP-binding protein
 +
**[[3zua]] - EcABC alpha-hemolysin transporter C39-like domain – NMR<br />
**[[2pmk]] - EcABC α-hemolysin transporter NBD+TNP-ADP<br />
**[[2pmk]] - EcABC α-hemolysin transporter NBD+TNP-ADP<br />
**[[2ff7]] - EcABC α-hemolysin transporter NBD+ADP<br />
**[[2ff7]] - EcABC α-hemolysin transporter NBD+ADP<br />
Line 287: Line 328:
**[[1l7v]] - EcABC vitamin B12 transporter+BtuD<br />
**[[1l7v]] - EcABC vitamin B12 transporter+BtuD<br />
**[[3p7i]], [[3qk6]], [[3quj]], [[3s4u]] – EcABC alkylphosphonate transporter PHND + aminoethyl phosphonic acid<br />
**[[3p7i]], [[3qk6]], [[3quj]], [[3s4u]] – EcABC alkylphosphonate transporter PHND + aminoethyl phosphonic acid<br />
 +
**[[7s6g]] - SsABC phosphonate transporter + PO4<br />
 +
**[[7s6e]] - SsABC urea transporter + urea<br />
**[[1twy]] - VcABC phosphate transporter <br />
**[[1twy]] - VcABC phosphate transporter <br />
**[[4n13]] - BbABC phosphate transporter (mutant)<br />
**[[4n13]] - BbABC phosphate transporter (mutant)<br />
-
**[[3l6g]], [[3l6h]] – LlABC OpuAC betaine transporter SBD <br />
+
**[[4exl]] - SpABC phosphate transporter<br />
 +
**[[4q8r]] - CpABC phosphate transporter + PO4<br />
**[[2zzv]] - TtABC solute transporter+lactate+Ca<br />
**[[2zzv]] - TtABC solute transporter+lactate+Ca<br />
**[[2zzw]] - TtABC solute transporter+lactate+Zn<br />
**[[2zzw]] - TtABC solute transporter+lactate+Zn<br />
Line 295: Line 339:
**[[3gfv]] - BsABC petrobactin transporter <br />
**[[3gfv]] - BsABC petrobactin transporter <br />
**[[3bk7]] – ABC ATP-binding – ''Pyrococcus abyssi''<br />
**[[3bk7]] – ABC ATP-binding – ''Pyrococcus abyssi''<br />
-
**[[3ppn]] - BsABC multiple solute transporter<br />
 
-
**[[3ppo]], [[3ppp]], [[3ppq]], [[3ppr]] - BsABC multiple solute transporter + solute<br />
 
**[[3hn0]] – ABC NO3 transporter – ''Parabacteroides distasonis''<br />
**[[3hn0]] – ABC NO3 transporter – ''Parabacteroides distasonis''<br />
**[[3rlb]] - LlABC vitamin B1 transporter + thiamin<br />
**[[3rlb]] - LlABC vitamin B1 transporter + thiamin<br />
Line 304: Line 346:
**[[2q6h]] – AaABC serotonin transporter - ''Aquifex aeolicus''<br />
**[[2q6h]] – AaABC serotonin transporter - ''Aquifex aeolicus''<br />
**[[6oih]], [[6an5]], [[6amx]] – AaABC O-antigen polysaccharide transporter <br />
**[[6oih]], [[6an5]], [[6amx]] – AaABC O-antigen polysaccharide transporter <br />
 +
**[[6m96]] – AaABC O-antigen polysaccharide transporter + ATP<br />
 +
**[[7k2t]] – AaABC O-antigen polysaccharide transporter + ATP – Cryo EM<br />
**[[6hnp]] – ABC O-antigen polysaccharide transporter – ''Raoultella ornithinolytica''<br />
**[[6hnp]] – ABC O-antigen polysaccharide transporter – ''Raoultella ornithinolytica''<br />
* hABC transporters subfamilies
* hABC transporters subfamilies
 +
**[[7roq]], [[7tby]], [[7tc0]] – hABCA1 + cholesterol – Cryo EM<br />
 +
**[[7tbz]] – hABCA1 (mutant) + cholesterol – Cryo EM<br />
 +
**[[7tbw]] – hABCA1 (mutant) + cholesterol + ATP – Cryo EM<br />
**[[3nh6]] – hABCB6 NBD<br />
**[[3nh6]] – hABCB6 NBD<br />
**[[3nhb]] – hABCB6 NBD+ADP<br />
**[[3nhb]] – hABCB6 NBD+ADP<br />
**[[3nh9]] – hABCB6 NBD+ATP<br />
**[[3nh9]] – hABCB6 NBD+ATP<br />
**[[3nha]] – hABCB6 NBD+ATP+Mg <br />
**[[3nha]] – hABCB6 NBD+ATP+Mg <br />
-
**[[6ffc]] – hABCG2 multidrug transporter + inhibitor – Cryo EM<br />
+
**[[7s5v]] – hABCC8 + ADP + ATP – Cryo EM<br />
-
**[[5nj3]] – hABCG2 multidrug transporter (mutant) + antibody – Cryo EM<br />
+
**[[7s5x]], [[7s5y]], [[7s5z]], [[7s60]], [[7s61]], [[7w4o]] – hABCC8 + potassium channel + ADP + ATP – Cryo EM<br />
-
**[[6hbu]] – hABCG2 multidrug transporter (mutant) + ATP – Cryo EM<br />
+
**[[7rr9]], [[7rra]], [[7vwc]] – hABCD1 – Cryo EM<br />
-
**[[6hco]] – hABCG2 multidrug transporter (mutant) + antibody + estrone sulfate – Cryo EM<br />
+
**[[7shn]], [[7vzb]] – hABCD1 + CoA derivative – Cryo EM<br />
 +
**[[7vx8]], [[7shm]] – hABCD1 + ATP – Cryo EM<br />
 +
**[[7r8d]], [[7fd7]] – hABCG1 + cholesterol – Cryo EM<br />
 +
**[[7dny]] – hABCG1 + coproporphyrin – Cryo EM<br />
 +
**[[7oz1]], [[7r8e]] – hABCG1 (mutant) + cholesterol + ATP – Cryo EM<br />
 +
**[[7a65]] – hABCG1 + antibody + cholesterol – Cryo EM<br />
 +
**[[7o9w]] – hABCG1 + drug + antibody – Cryo EM<br />
 +
**[[7a69]], [[7a6c]], [[7a6e]], [[7a6f]] – hABCG1 + drug + antibody + cholesterol – Cryo EM<br />
 +
**[[7ojh]] – hABCG2 + drug – Cryo EM<br />
 +
**[[7oji]] – hABCG2 + drug + cholesterol – Cryo EM<br />
 +
**[[7neq]], [[7nez]], [[7nfd]] – hABCG2 + drug + antibody – Cryo EM<br />
 +
**[[7niu]] – hABCG4 + antibody + cholesterol – Cryo EM<br />
 +
**[[7niv]] – hABCG4 + antibody + cholesterol + phosphatidylcholine – Cryo EM<br />
 +
**[[7niw]] – hABCG4 + antibody + cholesterol + drug – Cryo EM<br />
 +
**[[7d7n]], [[7d7r]], [[7ekm]] – hABCG6 core domain – Cryo EM<br />
 +
**[[7dnz]] – hABCG6 + glutathione + drug – Cryo EM<br />
 +
**[[7r87]], [[7r88]], [[7r89]] – hABCG5 + hABCG6 + antibody – Cryo EM<br />
 +
**[[7r8b]] – hABCG5 + hABCG6 + antibody + cholesterol – Cryo EM<br />
 +
**[[7jr7]], [[7r8a]] – hABCG5 + hABCG8 + antibody + cholesterol – Cryo EM<br />
 +
**[[5do7]] – hABCG5 sterol transporter + hABCG8 <br />
 +
 
 +
*Non-human ABC transporters subfamilies
 +
 
 +
**[[7oti]] – mABCG1A – Cryo EM<br />
 +
**[[7otg]] – mABCG1A + drug – Cryo EM<br />
 +
**[[7vlr]] – rABCC9 + ADP + ATP – Cryo EM<br />
 +
**[[7vls]], [[7vlt]], [[7vlu]] – rABCC9 + drug + ADP + ATP – Cryo EM<br />
 +
 
 +
*Lipoprotein-release ABC transporter LolCDE
 +
 
 +
**[[7ari]], [[7mdx]] – EcLolC + LolD + LolE – Cryo EM<br />
 +
**[[7ark]], [[7mdy]] – EcLolC + LolD + LolE + nucleotide – Cryo EM<br />
 +
**[[7arj]], [[7arl]] – EcLolC + LolD + LolE + lipoprotein + nucleotide – Cryo EM<br />
 +
**[[7arh]] – EcLolC + LolD + LolE + lipoprotein – Cryo EM<br />
 +
**[[7arm]] – EcLolC + LolD + LolE + lipoprotein + LolA – Cryo EM<br />
 +
**[[5naa]] – EcLolC<br />
 +
**[[6f49]] – EcLolC periplasmic domain <br />
 +
**[[6f3z]] – EcLolC periplasmic domain + LolA<br />
 +
**[[2pcj]], [[2pcl]] – AaLolD <br />
 +
**[[5udf]] – LolE N-terminal – ''Acinetobacter baumannii<''br />
* ABC unspecified transporters
* ABC unspecified transporters
Line 329: Line 415:
**[[4ayt]], [[3zdq]], [[4ayt]], [[4ayw]], [[4ayx]] - hABC transporter B 10<br />
**[[4ayt]], [[3zdq]], [[4ayt]], [[4ayw]], [[4ayx]] - hABC transporter B 10<br />
**[[4g68]] – ABC transporter - ''Caldanaerobius''<br />
**[[4g68]] – ABC transporter - ''Caldanaerobius''<br />
-
**[[4wwh]] – ABC transporter + galactose – ''Mycobacterium smegmatis''<br />
+
**[[4wwh]] – MsABC transporter + galactose <br />
* Cystic fibrosis transmembrane conductance regulator (CFTR)
* Cystic fibrosis transmembrane conductance regulator (CFTR)
Line 335: Line 421:
**[[6o2p]], [[6o1v]] – hCFTR + peptide – Cryo EM <br />
**[[6o2p]], [[6o1v]] – hCFTR + peptide – Cryo EM <br />
**[[6msm]] – hCFTR + peptide + cholesterol + ATP – Cryo EM <br />
**[[6msm]] – hCFTR + peptide + cholesterol + ATP – Cryo EM <br />
 +
**[[7svr]] – hCFTR + drug – Cryo EM <br />
 +
**[[7sv7]], [[7svd]] – hCFTR + drug + ATP – Cryo EM <br />
**[[3gd7]] – hCFTR/malK+N6-phenylethyl-ATP<br />
**[[3gd7]] – hCFTR/malK+N6-phenylethyl-ATP<br />
**[[2pze]], [[2pzf]], [[2pzg]], [[5uak]] – hCFTR NBD1<br />
**[[2pze]], [[2pzf]], [[2pzg]], [[5uak]] – hCFTR NBD1<br />
Line 340: Line 428:
**[[1xmi]], [[2xmj]], [[1xmj]], [[5tf7]], [[5tf8]], [[5tfa]], [[5tfb]], [[5tfc]], [[5tfd]], [[5tff]], [[5tfg]], [[5tfi]], [[5tfj]], [[4wz6]], [[5tgk]] - hCFTR NBD1 (mutant)+ nucleotide<br />
**[[1xmi]], [[2xmj]], [[1xmj]], [[5tf7]], [[5tf8]], [[5tfa]], [[5tfb]], [[5tfc]], [[5tfd]], [[5tff]], [[5tfg]], [[5tfi]], [[5tfj]], [[4wz6]], [[5tgk]] - hCFTR NBD1 (mutant)+ nucleotide<br />
**[[6gkd]], [[6gk4]], [[6gju]], [[6gjs]], [[6gjq]] - hCFTR NBD1 (mutant) + antibody<br />
**[[6gkd]], [[6gk4]], [[6gju]], [[6gjs]], [[6gjq]] - hCFTR NBD1 (mutant) + antibody<br />
 +
**[[6uk1]] - hCFTR NBD2 (mutant) + ATP<br />
**[[1xf9]], [[2xfa]], [[1xfa]], [[3si7]] - mCFTR NBD1 (mutant) - mouse<br />
**[[1xf9]], [[2xfa]], [[1xfa]], [[3si7]] - mCFTR NBD1 (mutant) - mouse<br />
**[[1q3h]] - mCFTR NBD1+AMPPNP<br />
**[[1q3h]] - mCFTR NBD1+AMPPNP<br />

Current revision

3D Structures of ABC transporter

Updated on 19-November-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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