This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Sodium-hydrogen exchange regulatory factor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:32, 21 November 2023) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 4: Line 4:
== Function ==
== Function ==
-
'''Sodium-hydrogen exchange regulatory factors''' (NHERF) are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>.
+
'''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' or '''Na+/H+ exchange regulatory cofactor NHE-RF1''' or '''NHERF''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>.
== Relevance ==
== Relevance ==
Line 14: Line 14:
NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal. The CXCR2 peptide binds the second PDZ domain hydrophobic cleft<ref>PMID:26010555</ref>.
NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal. The CXCR2 peptide binds the second PDZ domain hydrophobic cleft<ref>PMID:26010555</ref>.
-
</StructureSection>
 
== 3D Structures of sodium-hydrogen exchange regulatory factor ==
== 3D Structures of sodium-hydrogen exchange regulatory factor ==
 +
[[Sodium-hydrogen exchange regulatory factor 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
-
{{#tree:id=OrganizedByTopic|openlevels=0|
 
- 
-
*Sodium-hydrogen exchange regulatory factor 1
 
- 
-
**[[1g9o]], [[1gq5]] – hNHERF-1 PDZ 1 domain – human <br />
 
-
**[[2m0t]] – hNHERF-1 PDZ 1 domain - NMR <br />
 
-
**[[1i92]], [[4jl7]], [[4lmm]], [[4mpa]], [[4n6x]] - hNHERF-1 PDZ 1 domain/CFTR C-terminal peptide <br />
 
-
**[[4pqw]] - hNHERF-1 PDZ 1 domain/phospholipase C peptide <br />
 
-
**[[2m0u]] – hNHERF-1 PDZ 1 domain + CFTR C-terminal peptide - NMR <br />
 
-
**[[2ozf]] – hNHERF-1 PDZ 2 domain <br />
 
-
**[[4q3h]] – hNHERF-1 PDZ 2 domain/CXCR2 peptide <br />
 
-
**[[2jxo]], [[2kjd]] – hNHERF-1 PDZ 2 domain - NMR <br />
 
-
**[[2m0w]] – hNHERF-1 PDZ 2 domain + CFTR C-terminal peptide - NMR <br />
 
-
**[[2krg]] – hNHERF-1 residues 150-358 - NMR <br />
 
- 
-
*Sodium-hydrogen exchange regulatory factor 2
 
- 
-
**[[2ocs]] – hNHERF-2 PDZ 1 domain <br />
 
-
**[[2he4]] – hNHERF-2 PDZ 2 domain (mutant)<br />
 
- 
-
*Sodium-hydrogen exchange regulatory factor 3 or PDZK1
 
- 
-
**[[3ngh]] – mNHERF-3 PDZ 1 domain/HDL receptor - mouse<br />
 
-
**[[4f8k]] – mNHERF-3 PDZ 1 domain (mutant)/prostacyclin receptor<br />
 
-
**[[4q2p]] – hNHERF-3 PDZ 2 domain/phage peptide <br />
 
-
**[[3r68]] – mNHERF-3 PDZ 3 domain<br />
 
-
**[[3r69]] – mNHERF-3 PDZ 3 domain/HDL receptor<br />
 
-
**[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br />
 
-
**[[4r2z]] – mNHERF-3 PDZ 4 domain <br />
 
-
}}
 
== References ==
== References ==
<references/>
<references/>
-
 
+
</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human NHERF-1 second PDZ domain with CXCR2 peptide chimera (PDB cod 4q3h)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Sodium-hydrogen_exchange_regulatory_factor"
Personal tools