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Sodium-hydrogen exchange regulatory factor

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NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal. The CXCR2 peptide binds the second PDZ domain hydrophobic cleft<ref>PMID:26010555</ref>.
NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal. The CXCR2 peptide binds the second PDZ domain hydrophobic cleft<ref>PMID:26010555</ref>.
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</StructureSection>
 
== 3D Structures of sodium-hydrogen exchange regulatory factor ==
== 3D Structures of sodium-hydrogen exchange regulatory factor ==
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[[Sodium-hydrogen exchange regulatory factor 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Sodium-hydrogen exchange regulatory factor 1; Domains – PDZ 1 11-120; PDZ 2 150-235; PDZ 3 246-335; PDZ 4 375-459
 
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**[[1g9o]], [[1gq5]], [[1gq4]] – hNHERF-1 PDZ 1 domain – human <br />
 
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**[[2m0t]] – hNHERF-1 PDZ 1 domain - NMR <br />
 
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**[[1i92]], [[4jl7]], [[4lmm]], [[4mpa]], [[4n6x]] - hNHERF-1 PDZ 1 domain/CFTR C-terminal peptide <br />
 
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**[[4pqw]] - hNHERF-1 PDZ 1 domain/phospholipase C peptide <br />
 
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**[[2m0u]] – hNHERF-1 PDZ 1 domain + CFTR C-terminal peptide - NMR <br />
 
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**[[2ozf]] – hNHERF-1 PDZ 2 domain <br />
 
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**[[4q3h]] – hNHERF-1 PDZ 2 domain/CXCR2 peptide <br />
 
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**[[2jxo]], [[2kjd]] – hNHERF-1 PDZ 2 domain - NMR <br />
 
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**[[2m0w]], [[2m0v]] – hNHERF-1 PDZ 2 domain + CFTR C-terminal peptide - NMR <br />
 
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**[[2krg]] – hNHERF-1 residues 150-358 - NMR <br />
 
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*Sodium-hydrogen exchange regulatory factor 2
 
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**[[2ocs]] – hNHERF-2 PDZ 1 domain <br />
 
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**[[2he4]] – hNHERF-2 PDZ 2 domain (mutant)<br />
 
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*Sodium-hydrogen exchange regulatory factor 3 or PDZK1
 
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**[[3ngh]] – mNHERF-3 PDZ 1 domain/HDL receptor - mouse<br />
 
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**[[4f8k]] – mNHERF-3 PDZ 1 domain (mutant)/prostacyclin receptor<br />
 
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**[[2edz]] – mNHERF-3 PDZ 1 domain - NMR<br />
 
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**[[4q2p]] – hNHERF-3 PDZ 2 domain/phage peptide <br />
 
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**[[2eei]] – mNHERF-3 PDZ 2 domain - NMR<br />
 
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**[[2v90]] – hNHERF-3 PDZ 3 domain <br />
 
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**[[3r69]] – mNHERF-3 PDZ 3 domain/HDL receptor<br />
 
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**[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br />
 
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**[[3r68]] – mNHERF-3 PDZ 3 domain<br />
 
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**[[2d90]] – mNHERF-3 PDZ 3 domain - NMR<br />
 
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**[[2vsp]] – hNHERF-3 PDZ 4 domain <br />
 
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**[[6ezi]] – hNHERF-3 PDZ 4 domain + peptide transporter peptide<br />
 
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**[[4r2z]] – mNHERF-3 PDZ 4 domain <br />
 
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**[[2edz]] – mNHERF-3 PDZ 4 domain - NMR<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human NHERF-1 second PDZ domain with CXCR2 peptide chimera (PDB cod 4q3h)

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