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5wz2

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Current revision (07:51, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5wz2' size='340' side='right'caption='[[5wz2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='5wz2' size='340' side='right'caption='[[5wz2]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wz2]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5WZ2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wz2]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WZ2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wz1|5wz1]], [[5wz3|5wz3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTA:P1-7-METHYLGUANOSINE-P3-ADENOSINE-5,5-TRIPHOSPHATE'>GTA</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5wz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wz2 OCA], [http://pdbe.org/5wz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wz2 RCSB], [http://www.ebi.ac.uk/pdbsum/5wz2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wz2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wz2 OCA], [https://pdbe.org/5wz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wz2 RCSB], [https://www.ebi.ac.uk/pdbsum/5wz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wz2 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A109PRQ3_ZIKV A0A109PRQ3_ZIKV] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[ARBA:ARBA00003504] Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3.[PROSITE-ProRule:PRU00859]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Duan, W]]
 
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[[Category: Gao, G F]]
 
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[[Category: Qi, J]]
 
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[[Category: Shi, Y]]
 
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[[Category: Song, H]]
 
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[[Category: Methytransferase]]
 
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[[Category: Rna analogue]]
 
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[[Category: Sam]]
 
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[[Category: Transferase]]
 
[[Category: Zika virus]]
[[Category: Zika virus]]
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[[Category: Duan W]]
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[[Category: Gao GF]]
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[[Category: Qi J]]
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[[Category: Shi Y]]
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[[Category: Song H]]

Current revision

Crystal structure of Zika virus NS5 methyltransferase bound to SAM and RNA analogue (m7GpppA)

PDB ID 5wz2

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OCA

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