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5x61
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5x61 is ON HOLD until Paper Publication Authors: Han, Q., Robinson, H., Ding, H., Wong, D.M., Lam, P.C.H., Totrov, M.M., Carlier, P.R., Li, J. Desc...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Acetylcholinesterase Catalytic Subunit of the Malaria Vector Anopheles Gambiae, 3.4 A== | |
| + | <StructureSection load='5x61' size='340' side='right'caption='[[5x61]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5x61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X61 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x61 OCA], [https://pdbe.org/5x61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x61 RCSB], [https://www.ebi.ac.uk/pdbsum/5x61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x61 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACES_ANOGA ACES_ANOGA] Rapidly hydrolyzes choline released into the synapse. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Acetylcholinesterase (AChE) hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses in the central nervous system (Toutant, 1989). Inhibition of the enzyme in insects could lead to the death of insects rapidly; thus AChE has been a molecular target for developing insecticides. This article is protected by copyright. All rights reserved. | ||
| - | + | Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae.,Han Q, Wong DM, Robinson H, Ding H, Lam PC, Totrov MM, Carlier PR, Li J Insect Sci. 2017 Mar 1. doi: 10.1111/1744-7917.12450. PMID:28247978<ref>PMID:28247978</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5x61" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: | + | ==See Also== |
| - | [[Category: Lam | + | *[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]] |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Anopheles gambiae]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Carlier PR]] | ||
| + | [[Category: Ding H]] | ||
| + | [[Category: Han Q]] | ||
| + | [[Category: Lam PCH]] | ||
| + | [[Category: Li J]] | ||
| + | [[Category: Robinson H]] | ||
| + | [[Category: Totrov MM]] | ||
| + | [[Category: Wong DM]] | ||
Current revision
Crystal structure of Acetylcholinesterase Catalytic Subunit of the Malaria Vector Anopheles Gambiae, 3.4 A
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Categories: Anopheles gambiae | Large Structures | Carlier PR | Ding H | Han Q | Lam PCH | Li J | Robinson H | Totrov MM | Wong DM
