5x61

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'''Unreleased structure'''
 
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The entry 5x61 is ON HOLD until Paper Publication
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==Crystal structure of Acetylcholinesterase Catalytic Subunit of the Malaria Vector Anopheles Gambiae, 3.4 A==
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<StructureSection load='5x61' size='340' side='right'caption='[[5x61]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5x61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X61 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x61 OCA], [https://pdbe.org/5x61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x61 RCSB], [https://www.ebi.ac.uk/pdbsum/5x61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x61 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACES_ANOGA ACES_ANOGA] Rapidly hydrolyzes choline released into the synapse.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Acetylcholinesterase (AChE) hydrolyzes the neurotransmitter acetylcholine at cholinergic synapses in the central nervous system (Toutant, 1989). Inhibition of the enzyme in insects could lead to the death of insects rapidly; thus AChE has been a molecular target for developing insecticides. This article is protected by copyright. All rights reserved.
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Authors: Han, Q., Robinson, H., Ding, H., Wong, D.M., Lam, P.C.H., Totrov, M.M., Carlier, P.R., Li, J.
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Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae.,Han Q, Wong DM, Robinson H, Ding H, Lam PC, Totrov MM, Carlier PR, Li J Insect Sci. 2017 Mar 1. doi: 10.1111/1744-7917.12450. PMID:28247978<ref>PMID:28247978</ref>
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Description: Crystal structure of Acetylcholinesterase Catalytic Subunit of the Malaria Vector Anopheles Gambiae, 3.4 A
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Li, J]]
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<div class="pdbe-citations 5x61" style="background-color:#fffaf0;"></div>
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[[Category: Robinson, H]]
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[[Category: Carlier, P.R]]
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==See Also==
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[[Category: Lam, P.C.H]]
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*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
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[[Category: Totrov, M.M]]
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== References ==
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[[Category: Ding, H]]
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<references/>
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[[Category: Wong, D.M]]
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__TOC__
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[[Category: Han, Q]]
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</StructureSection>
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[[Category: Anopheles gambiae]]
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[[Category: Large Structures]]
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[[Category: Carlier PR]]
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[[Category: Ding H]]
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[[Category: Han Q]]
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[[Category: Lam PCH]]
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[[Category: Li J]]
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[[Category: Robinson H]]
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[[Category: Totrov MM]]
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[[Category: Wong DM]]

Current revision

Crystal structure of Acetylcholinesterase Catalytic Subunit of the Malaria Vector Anopheles Gambiae, 3.4 A

PDB ID 5x61

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