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5x74

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==The crystal Structure PDE delta in complex with compound (R, R)-1g==
==The crystal Structure PDE delta in complex with compound (R, R)-1g==
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<StructureSection load='5x74' size='340' side='right' caption='[[5x74]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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<StructureSection load='5x74' size='340' side='right'caption='[[5x74]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5x74]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X74 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5x74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X74 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JAY:(2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one'>JAY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5x72|5x72]], [[5x73|5x73]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JAY:(2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one'>JAY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x74 OCA], [http://pdbe.org/5x74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x74 RCSB], [http://www.ebi.ac.uk/pdbsum/5x74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x74 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x74 OCA], [https://pdbe.org/5x74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x74 RCSB], [https://www.ebi.ac.uk/pdbsum/5x74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x74 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
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[https://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, L]]
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[[Category: Homo sapiens]]
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[[Category: Jiang, Y]]
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[[Category: Large Structures]]
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[[Category: Sheng, C]]
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[[Category: Chen L]]
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[[Category: Wang, F]]
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[[Category: Jiang Y]]
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[[Category: Wang, R]]
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[[Category: Sheng C]]
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[[Category: Zhuang, C]]
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[[Category: Wang F]]
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[[Category: Lipid binding protein]]
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[[Category: Wang R]]
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[[Category: Zhuang C]]

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The crystal Structure PDE delta in complex with compound (R, R)-1g

PDB ID 5x74

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