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5x8g

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==Binary complex structure of a double mutant I454RA456K of o-Succinylbenzoate CoA Synthetase (MenE) from Bacillus Subtilis bound with its product analogue OSB-NCoA at 1.90 angstrom==
==Binary complex structure of a double mutant I454RA456K of o-Succinylbenzoate CoA Synthetase (MenE) from Bacillus Subtilis bound with its product analogue OSB-NCoA at 1.90 angstrom==
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<StructureSection load='5x8g' size='340' side='right' caption='[[5x8g]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5x8g' size='340' side='right'caption='[[5x8g]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5x8g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X8G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5x8g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X8G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=S0N:O-SUCCINYLBENZOYL-N-COENZYME+A'>S0N</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/o-succinylbenzoate--CoA_ligase o-succinylbenzoate--CoA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.2.1.26 6.2.1.26] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=S0N:O-SUCCINYLBENZOYL-N-COENZYME+A'>S0N</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8g OCA], [http://pdbe.org/5x8g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x8g RCSB], [http://www.ebi.ac.uk/pdbsum/5x8g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8g ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x8g OCA], [https://pdbe.org/5x8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x8g RCSB], [https://www.ebi.ac.uk/pdbsum/5x8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x8g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MENE_BACSU MENE_BACSU]] Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).[HAMAP-Rule:MF_00731]
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[https://www.uniprot.org/uniprot/MENE_BACSU MENE_BACSU] Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA).[HAMAP-Rule:MF_00731]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: O-succinylbenzoate--CoA ligase]]
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[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Chen, Y]]
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[[Category: Large Structures]]
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[[Category: Guo, Z]]
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[[Category: Chen Y]]
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[[Category: Acyl-coa synthetase]]
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[[Category: Guo Z]]
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[[Category: Adenylate-forming enzyme]]
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[[Category: Adp binding subsite]]
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[[Category: Coa]]
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[[Category: Domain alternation]]
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[[Category: Inter-domain linker]]
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[[Category: Large conformational change]]
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[[Category: Ligase]]
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[[Category: Pantetheine tunnel]]
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[[Category: Thioester conformation]]
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Current revision

Binary complex structure of a double mutant I454RA456K of o-Succinylbenzoate CoA Synthetase (MenE) from Bacillus Subtilis bound with its product analogue OSB-NCoA at 1.90 angstrom

PDB ID 5x8g

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