5xmx

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==Co-crystal structure of Inhibitor compound in complex with human PPARdelta LBD==
==Co-crystal structure of Inhibitor compound in complex with human PPARdelta LBD==
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<StructureSection load='5xmx' size='340' side='right' caption='[[5xmx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5xmx' size='340' side='right'caption='[[5xmx]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5xmx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XMX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5xmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XMX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=89L:(E)-6-[2-[[[4-(furan-2-yl)phenyl]carbonyl-methyl-amino]methyl]phenoxy]-4-methyl-hex-4-enoic+acid'>89L</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xmx OCA], [http://pdbe.org/5xmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xmx RCSB], [http://www.ebi.ac.uk/pdbsum/5xmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xmx ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=89L:(E)-6-[2-[[[4-(furan-2-yl)phenyl]carbonyl-methyl-amino]methyl]phenoxy]-4-methyl-hex-4-enoic+acid'>89L</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xmx OCA], [https://pdbe.org/5xmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xmx RCSB], [https://www.ebi.ac.uk/pdbsum/5xmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xmx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
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[https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5xmx" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5xmx" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Krishnamurthy, N]]
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[[Category: Homo sapiens]]
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[[Category: Lakshminarasimhan, A]]
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[[Category: Large Structures]]
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[[Category: Rani, S T]]
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[[Category: Krishnamurthy N]]
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[[Category: Senaiar, R S]]
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[[Category: Lakshminarasimhan A]]
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[[Category: Inhibitor compound]]
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[[Category: Rani ST]]
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[[Category: Ppardelta]]
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[[Category: Senaiar RS]]
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[[Category: Transcription-inhibitor complex]]
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Co-crystal structure of Inhibitor compound in complex with human PPARdelta LBD

PDB ID 5xmx

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