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5y41

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Current revision (08:21, 22 November 2023) (edit) (undo)
 
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<StructureSection load='5y41' size='340' side='right'caption='[[5y41]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
<StructureSection load='5y41' size='340' side='right'caption='[[5y41]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5y41]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y41 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5Y41 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5y41]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y41 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=RPG:(13E,15S)-15-hydroxy-9-oxoprosta-10,13-dien-1-oic+acid'>RPG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR4A2, NOT, NURR1, TINUR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=RPG:(13E,15S)-15-hydroxy-9-oxoprosta-10,13-dien-1-oic+acid'>RPG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5y41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y41 OCA], [http://pdbe.org/5y41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y41 RCSB], [http://www.ebi.ac.uk/pdbsum/5y41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y41 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y41 OCA], [https://pdbe.org/5y41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y41 RCSB], [https://www.ebi.ac.uk/pdbsum/5y41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y41 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NR4A2_HUMAN NR4A2_HUMAN]] Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
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[https://www.uniprot.org/uniprot/NR4A2_HUMAN NR4A2_HUMAN] Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lescar, J]]
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[[Category: Lescar J]]
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[[Category: Sreekanth, R]]
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[[Category: Sreekanth R]]
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[[Category: Yoon, H S]]
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[[Category: Yoon HS]]
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[[Category: Lbd]]
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[[Category: Michael addition]]
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[[Category: Nurr1]]
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[[Category: Prostaglandin]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of LIGAND-BOUND NURR1-LBD

PDB ID 5y41

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