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5yak

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==The crystal structure of human IYD Thr239 mutant with ligand 3-Fluorotyrosine (F-Tyr)==
==The crystal structure of human IYD Thr239 mutant with ligand 3-Fluorotyrosine (F-Tyr)==
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<StructureSection load='5yak' size='340' side='right' caption='[[5yak]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='5yak' size='340' side='right'caption='[[5yak]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5yak]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YAK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5yak]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YAK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YAK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Iodotyrosine_deiodinase Iodotyrosine deiodinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.21.1.1 1.21.1.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=YOF:3-FLUOROTYROSINE'>YOF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yak OCA], [http://pdbe.org/5yak PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yak RCSB], [http://www.ebi.ac.uk/pdbsum/5yak PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yak ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yak FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yak OCA], [https://pdbe.org/5yak PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yak RCSB], [https://www.ebi.ac.uk/pdbsum/5yak PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yak ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/IYD1_HUMAN IYD1_HUMAN]] Familial thyroid dyshormonogenesis. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/IYD1_HUMAN IYD1_HUMAN] Familial thyroid dyshormonogenesis. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IYD1_HUMAN IYD1_HUMAN]] Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.<ref>PMID:15289438</ref>
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[https://www.uniprot.org/uniprot/IYD1_HUMAN IYD1_HUMAN] Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.<ref>PMID:15289438</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5yak" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5yak" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dehalogenase 3D structures|Dehalogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Iodotyrosine deiodinase]]
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[[Category: Homo sapiens]]
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[[Category: Hu, J M]]
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[[Category: Large Structures]]
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[[Category: Rokita, S E]]
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[[Category: Hu JM]]
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[[Category: Schlessman, J]]
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[[Category: Rokita SE]]
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[[Category: Fmn]]
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[[Category: Schlessman J]]
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[[Category: Hiyd]]
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[[Category: Mft]]
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[[Category: Oxidoreductase]]
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[[Category: T239a mutant]]
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Current revision

The crystal structure of human IYD Thr239 mutant with ligand 3-Fluorotyrosine (F-Tyr)

PDB ID 5yak

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