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5yks

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Crystal structure of sucrose nonfermenting-related kinase (SNRK)

Structural highlights

5yks is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.9Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SNRK_HUMAN May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.[UniProtKB:Q63553]^[1] ^[2]

Publication Abstract from PubMed

Sucrose non-fermenting (Snf1)-related kinase (SNRK) is a novel member of the AMP-activated protein kinase (AMPK) family and is involved in many metabolic processes. Here we report the crystal structure of an N-terminal SNRK fragment containing kinase and adjacent ubiquitin-associated (UBA) domains. This structure shows that the UBA domain binds between the N- and C-lobes of the kinase domain. The mode of UBA binding in SNRK largely resembles that in AMPK and brain specific kinase (BRSK), however, unique interactions play vital roles in stabilizing the KD-UBA interface of SNRK. We further propose a potential role of the UBA domain in the regulation of SNRK kinase activity. This study provides new insights into the structural diversities of the AMPK kinase family.

Crystal structure of the kinase and UBA domains of SNRK reveals a distinct UBA binding mode in the AMPK family.,Wang YL, Wang J, Chen X, Wang ZX, Wu JW Biochem Biophys Res Commun. 2017 Oct 20. pii: S0006-291X(17)32083-1. doi:, 10.1016/j.bbrc.2017.10.105. PMID:29061304^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kertesz N, Samson J, Debacker C, Wu H, Labastie MC. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene. 2002 Jul 10;294(1-2):13-24. PMID:12234663
↑ Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. FEBS Lett. 2005 Feb 28;579(6):1417-23. PMID:15733851 doi:S0014-5793(05)00141-9
↑ Wang YL, Wang J, Chen X, Wang ZX, Wu JW. Crystal structure of the kinase and UBA domains of SNRK reveals a distinct UBA binding mode in the AMPK family. Biochem Biophys Res Commun. 2017 Oct 20. pii: S0006-291X(17)32083-1. doi:, 10.1016/j.bbrc.2017.10.105. PMID:29061304 doi:http://dx.doi.org/10.1016/j.bbrc.2017.10.105

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5yks"

Categories: Homo sapiens | Large Structures | Wang J | Wang YL | Wu JW

@@ Line 1: / Line 1: @@
 ==Crystal structure of sucrose nonfermenting-related kinase (SNRK)==
-<StructureSection load='5yks' size='340' side='right' caption='[[5yks]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+<StructureSection load='5yks' size='340' side='right'caption='[[5yks]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5yks]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YKS FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5yks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YKS FirstGlance]. <br>
-</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yks OCA], [http://pdbe.org/5yks PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yks RCSB], [http://www.ebi.ac.uk/pdbsum/5yks PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yks ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yks OCA], [https://pdbe.org/5yks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yks RCSB], [https://www.ebi.ac.uk/pdbsum/5yks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yks ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/SNRK_HUMAN SNRK_HUMAN]] May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.[UniProtKB:Q63553]<ref>PMID:12234663</ref> <ref>PMID:15733851</ref>
+[https://www.uniprot.org/uniprot/SNRK_HUMAN SNRK_HUMAN] May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.[UniProtKB:Q63553]<ref>PMID:12234663</ref> <ref>PMID:15733851</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 18: / Line 18: @@
 </div>
 <div class="pdbe-citations 5yks" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Non-specific serine/threonine protein kinase]]
+[[Category: Homo sapiens]]
-[[Category: Wang, J]]
+[[Category: Large Structures]]
-[[Category: Wang, Y L]]
+[[Category: Wang J]]
-[[Category: Wu, J W]]
+[[Category: Wang YL]]
-[[Category: Protein kinase]]
+[[Category: Wu JW]]
-[[Category: Transferase]]
-[[Category: Uba domain]]

5yks

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Current revision

Crystal structure of sucrose nonfermenting-related kinase (SNRK)

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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