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5yv7
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==Racemic X-ray Structure of Calcicludine== | ==Racemic X-ray Structure of Calcicludine== | ||
| - | <StructureSection load='5yv7' size='340' side='right' caption='[[5yv7]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='5yv7' size='340' side='right'caption='[[5yv7]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5yv7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YV7 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5yv7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YV7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.395Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5yv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yv7 OCA], [https://pdbe.org/5yv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5yv7 RCSB], [https://www.ebi.ac.uk/pdbsum/5yv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5yv7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/VKTHC_DENAN VKTHC_DENAN] Potent blocker of high-voltage-activated calcium ion channels in the nanomolar range, particularly the L-type channels in cerebellar granule cells. The sensitivity of L-, N- and P-type channels to CAC is tissue and species-dependent. Blocks the L-type current of cardiac cells, depressing cardiac contractility. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Dendroaspis angusticeps]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | + | [[Category: Lei L]] | |
| - | + | [[Category: Qian Q]] | |
| - | [[Category: L | + | [[Category: Shuai G]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
Current revision
Racemic X-ray Structure of Calcicludine
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