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5z8o
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structural of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis== | |
| + | <StructureSection load='5z8o' size='340' side='right'caption='[[5z8o]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5z8o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Z8O FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5z8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8o OCA], [https://pdbe.org/5z8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5z8o RCSB], [https://www.ebi.ac.uk/pdbsum/5z8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/I7FVL6_MYCS2 I7FVL6_MYCS2] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Mycobacterium tuberculosis is a notorious pathogen that continues to threaten human health. Rv0164, an antigen of both T- and B-cells conserved across mycobacteria, and MSMEG_0129, its close homolog in Mycobacterium smegmatis, are predicted members of the START domain superfamily, but their molecular function is unknown. Here, gene knockout studies demonstrate MSMEG_0129 is essential for bacterial growth, suggesting Rv0164 may be a potential drug target. The MSMEG_0129 crystal structure determined at 1.95 A reveals a fold similar to that in polyketide aromatase/cyclases ZhuI and TcmN from Streptomyces sp. Structural comparisons and docking simulations, however, infer that MSMEG_0129 and Rv0164 are unlikely to catalyze polyketide aromatization/cyclization, but probably play an irreplaceable role during mycobacterial growth, for example in lipid transfer during cell envelope synthesis. This article is protected by copyright. All rights reserved. | ||
| - | + | Structural and genetic analysis of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis.,Zheng S, Zhou Y, Fleming J, Zhou Y, Zhang M, Li S, Li H, Sun B, Liu W, Bi L FEBS Lett. 2018 Mar 7. doi: 10.1002/1873-3468.13024. PMID:29512898<ref>PMID:29512898</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5z8o" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycolicibacterium smegmatis MC2 155]] | ||
| + | [[Category: Bi L]] | ||
| + | [[Category: Liu W]] | ||
| + | [[Category: Zheng S]] | ||
Current revision
Structural of START superfamily protein MSMEG_0129 from Mycobacterium smegmatis
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