This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6a27

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:14, 22 November 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal structure of PprA W183R mutant form 1==
==Crystal structure of PprA W183R mutant form 1==
-
<StructureSection load='6a27' size='340' side='right' caption='[[6a27]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
+
<StructureSection load='6a27' size='340' side='right'caption='[[6a27]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6a27]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A27 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6a27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6A27 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.353&#8491;</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a27 OCA], [http://pdbe.org/6a27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a27 RCSB], [http://www.ebi.ac.uk/pdbsum/6a27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a27 ProSAT]</span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6a27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a27 OCA], [https://pdbe.org/6a27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6a27 RCSB], [https://www.ebi.ac.uk/pdbsum/6a27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6a27 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA]] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref>
+
[https://www.uniprot.org/uniprot/PPRA_DEIRA PPRA_DEIRA] dsDNA-binding protein that contributes to the ionizing radiation resistance of D.radiodurans. Plays a role in DNA repair and genome reconstitution, and is necessary for recovery from severe genomic fragmentation as a result of exposure to severe levels of ionizing radiation. In vitro, binds to double-stranded DNA carrying strand breaks and stimulates the DNA end-joining reaction catalyzed by DNA ligases. Thus, PprA plays a critical role in a non-homologous end-joining (NHEJ) pathway for the repair of radiation-induced DNA double-strands breaks. Cannot bind to dsDNA without strand breaks or single-stranded DNA.<ref>PMID:15454524</ref> <ref>PMID:15458422</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Adachi, M]]
+
[[Category: Deinococcus radiodurans R1]]
-
[[Category: Arai, S]]
+
[[Category: Large Structures]]
-
[[Category: Kuroki, R]]
+
[[Category: Adachi M]]
-
[[Category: Narumi, I]]
+
[[Category: Arai S]]
-
[[Category: Satoh, K]]
+
[[Category: Kuroki R]]
-
[[Category: Shibazaki, C]]
+
[[Category: Narumi I]]
-
[[Category: Shimizu, R]]
+
[[Category: Satoh K]]
-
[[Category: Dna binding protein]]
+
[[Category: Shibazaki C]]
 +
[[Category: Shimizu R]]

Current revision

Crystal structure of PprA W183R mutant form 1

PDB ID 6a27

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6a27"
Personal tools