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6ipa

From Proteopedia

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Current revision

C-terminal EMAP II-like domain of p43 refined against twinned data

Structural highlights

6ipa is a 4 chain structure with sequence from Plasmodium vivax. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.47Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A5K3Y7_PLAVS

Publication Abstract from PubMed

Scaffold modules known as aminoacyl-tRNA synthetase (aaRS)-interacting multifunctional proteins (AIMPs), such as AIMP1/p43, AIMP2/p38 and AIMP3/p18, are important in driving the assembly of multi-aaRS (MARS) complexes in eukaryotes. Often, AIMPs contain an N-terminal glutathione S-transferase (GST)-like domain and a C-terminal OB-fold tRNA-binding domain. Recently, the apicomplexan-specific Plasmodium falciparum p43 protein (Pfp43) has been annotated as an AIMP and its tRNA binding, tRNA import and membrane association have been characterized. The crystal structures of both the N- and C-terminal domains of the Plasmodium vivax p43 protein (Pvp43), which is an ortholog of Pfp43, have been resolved. Analyses reveal the overall oligomeric structure of Pvp43 and highlight several notable features that show Pvp43 to be a soluble, cytosolic protein. The dimeric assembly of the N-terminal GST-like domain of Pvp43 differs significantly from canonical GST dimers, and it is tied to the C-terminal tRNA-binding domain via a linker region. This work therefore establishes a framework for dissecting the additional roles of p43 orthologs in eukaryotic multi-protein MARS complexes.

Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.,Gupta S, Chhibber-Goel J, Sharma M, Parvez S, Harlos K, Sharma A, Yogavel M Acta Crystallogr D Struct Biol. 2020 Feb 1;76(Pt 2):135-146. doi:, 10.1107/S2059798319016413. Epub 2020 Jan 30. PMID:32038044^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Gupta S, Chhibber-Goel J, Sharma M, Parvez S, Harlos K, Sharma A, Yogavel M. Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein. Acta Crystallogr D Struct Biol. 2020 Feb 1;76(Pt 2):135-146. doi:, 10.1107/S2059798319016413. Epub 2020 Jan 30. PMID:32038044 doi:http://dx.doi.org/10.1107/S2059798319016413

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6ipa"

@@ Line 3: / Line 3: @@
 <StructureSection load='6ipa' size='340' side='right'caption='[[6ipa]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6ipa]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemamoeba_vivax Haemamoeba vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IPA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IPA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6ipa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IPA FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ipa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ipa OCA], [http://pdbe.org/6ipa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ipa RCSB], [http://www.ebi.ac.uk/pdbsum/6ipa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ipa ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ipa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ipa OCA], [https://pdbe.org/6ipa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ipa RCSB], [https://www.ebi.ac.uk/pdbsum/6ipa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ipa ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A5K3Y7_PLAVS A5K3Y7_PLAVS]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 22: @@
 __TOC__
 </StructureSection>
-[[Category: Haemamoeba vivax]]
 [[Category: Large Structures]]
-[[Category: Gupta, S]]
+[[Category: Plasmodium vivax]]
-[[Category: Harlos, K]]
+[[Category: Gupta S]]
-[[Category: Manickam, Y]]
+[[Category: Harlos K]]
-[[Category: Sharma, A]]
+[[Category: Manickam Y]]
-[[Category: Aimp1]]
+[[Category: Sharma A]]
-[[Category: Emapii-like domain]]
-[[Category: Plasmodium]]
-[[Category: Rna binding protein]]

6ipa

From Proteopedia

Current revision

C-terminal EMAP II-like domain of p43 refined against twinned data

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

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