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6ird

From Proteopedia

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'''Unreleased structure'''
 
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The entry 6ird is ON HOLD until Paper Publication
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==Complex structure of INADL PDZ89 and PLCb4 C-terminal CC-PBM==
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<StructureSection load='6ird' size='340' side='right'caption='[[6ird]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ird]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IRD FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.813&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AU:GOLD+ION'>AU</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ird FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ird OCA], [https://pdbe.org/6ird PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ird RCSB], [https://www.ebi.ac.uk/pdbsum/6ird PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ird ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q91UZ1_MOUSE Q91UZ1_MOUSE] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.[PIRNR:PIRNR000956]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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INAD assembles key enzymes of the Drosophila compound eye photo-transduction pathway into a supramolecular complex, supporting efficient and fast light signaling. However, the molecular mechanism that governs the interaction between INAD and NORPA (phospholipase Cbeta, PLCbeta), a key step for the fast kinetics of the light signaling, is not known. Here, we show that the NORPA C-terminal coiled-coil domain and PDZ-binding motif (CC-PBM) synergistically bind to INAD PDZ45 tandem with an unexpected mode and unprecedented high affinity. Guided by the structure of the INAD-NORPA complex, we discover that INADL is probably a mammalian counterpart of INAD. The INADL PDZ89 tandem specifically binds to PLCbeta4 with a mode that is strikingly similar to that of the INAD-NORPA complex, as revealed by the structure of the INADL PDZ89-PLCbeta4 CC-PBM complex. Therefore, our study suggests that the highly specific PDZ tandem - PLCbeta interactions are an evolutionarily conserved mechanism in PLCbeta signaling in the animal kingdom.
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Authors: Ye, F., Li, J., Huang, Y., Liu, W., Zhang, M.
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An unexpected INAD PDZ tandem-mediated plcbeta binding in Drosophila photo receptors.,Ye F, Huang Y, Li J, Ma Y, Xie C, Liu Z, Deng X, Wan J, Xue T, Liu W, Zhang M Elife. 2018 Dec 10;7. pii: 41848. doi: 10.7554/eLife.41848. PMID:30526850<ref>PMID:30526850</ref>
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Description: Complex structure of INADL PDZ89 and PLCb4 C-terminal CC-PBM
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Zhang, M]]
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<div class="pdbe-citations 6ird" style="background-color:#fffaf0;"></div>
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[[Category: Liu, W]]
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== References ==
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[[Category: Ye, F]]
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<references/>
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[[Category: Li, J]]
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__TOC__
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[[Category: Huang, Y]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Huang Y]]
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[[Category: Li J]]
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[[Category: Liu W]]
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[[Category: Ye F]]
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[[Category: Zhang M]]

Current revision

Complex structure of INADL PDZ89 and PLCb4 C-terminal CC-PBM

PDB ID 6ird

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