This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6ivy
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of iron-bound HitA from Pseudomonas aeruginosa== | |
| + | <StructureSection load='6ivy' size='340' side='right'caption='[[6ivy]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ivy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IVY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IVY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9999994Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ivy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ivy OCA], [https://pdbe.org/6ivy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ivy RCSB], [https://www.ebi.ac.uk/pdbsum/6ivy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ivy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9HVA8_PSEAE Q9HVA8_PSEAE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Gallium nitrate (Ganite) is a potential drug for the treatment of Pseudomonas aeruginosa infection. CRISPR/Cas9-based gene mutagenesis studies reveal that siderophore pyochelin-facilitated uptake and an ABC transporter are two major Ga(3+) internalization pathways in Pseudomonas aeruginosa (P. aeruginosa). Crystal structures reveal that Ga(3+) and Fe(3+) occupy exactly the same metal site of HitA, a periplasmic iron-binding protein of the ABC transporter system. The study provides a molecular basis for Ga(3+) internalization by P. aeruginosa and facilitates gallium-based antimicrobial drug development. | ||
| - | + | Identification and Characterization of a Metalloprotein Involved in Gallium Internalization in Pseudomonas aeruginosa.,Guo Y, Li W, Li H, Xia W ACS Infect Dis. 2019 Oct 11;5(10):1693-1697. doi: 10.1021/acsinfecdis.9b00271., Epub 2019 Sep 5. PMID:31475514<ref>PMID:31475514</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6ivy" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: | + | ==See Also== |
| + | *[[Ferric-binding protein|Ferric-binding protein]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa PAO1]] | ||
| + | [[Category: Li HY]] | ||
| + | [[Category: Zhang ZR]] | ||
Current revision
Crystal structure of iron-bound HitA from Pseudomonas aeruginosa
| |||||||||||
