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6jkh

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Current revision (10:13, 22 November 2023) (edit) (undo)
 
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==cholesterol-decarboxylating enzyme 2==
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==The NAD+-bound form of human NSDHL==
<StructureSection load='6jkh' size='340' side='right'caption='[[6jkh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='6jkh' size='340' side='right'caption='[[6jkh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6jkh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JKH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jkh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JKH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NSDHL, H105E3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-beta-hydroxysteroid-4-alpha-carboxylate_3-dehydrogenase_(decarboxylating) 3-beta-hydroxysteroid-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.170 1.1.1.170] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkh OCA], [https://pdbe.org/6jkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jkh RCSB], [https://www.ebi.ac.uk/pdbsum/6jkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jkh OCA], [http://pdbe.org/6jkh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jkh RCSB], [http://www.ebi.ac.uk/pdbsum/6jkh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jkh ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/NSDHL_HUMAN NSDHL_HUMAN]] CHILD syndrome;CK syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/NSDHL_HUMAN NSDHL_HUMAN] CHILD syndrome;CK syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NSDHL_HUMAN NSDHL_HUMAN]] Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis.<ref>PMID:14506130</ref>
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[https://www.uniprot.org/uniprot/NSDHL_HUMAN NSDHL_HUMAN] Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis.<ref>PMID:14506130</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kim, D]]
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[[Category: Kim D]]
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[[Category: Lee, B]]
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[[Category: Lee B]]
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[[Category: Lee, S J]]
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[[Category: Lee SJ]]
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[[Category: Cholesterol]]
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[[Category: Dehydrogenase]]
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[[Category: Oxidoreductase]]
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Current revision

The NAD+-bound form of human NSDHL

PDB ID 6jkh

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