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6jt3

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Current revision (10:19, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6jt3' size='340' side='right'caption='[[6jt3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='6jt3' size='340' side='right'caption='[[6jt3]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6jt3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JT3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JT3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JT3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C83:N-[3-[(4R,5R,6R)-2-azanyl-5-fluoranyl-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide'>C83</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C83:N-[3-[(4R,5R,6R)-2-azanyl-5-fluoranyl-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide'>C83</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jt3 OCA], [https://pdbe.org/6jt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jt3 RCSB], [https://www.ebi.ac.uk/pdbsum/6jt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jt3 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jt3 OCA], [http://pdbe.org/6jt3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jt3 RCSB], [http://www.ebi.ac.uk/pdbsum/6jt3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jt3 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
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[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6jt3" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6jt3" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Memapsin 2]]
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[[Category: Ando S]]
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[[Category: Ando, S]]
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[[Category: Asada N]]
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[[Category: Asada, N]]
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[[Category: Austin N]]
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[[Category: Austin, N]]
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[[Category: Bergh AVD]]
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[[Category: Bergh, A V.D]]
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[[Category: Borghys H]]
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[[Category: Borghys, H]]
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[[Category: Dhuyvetter D]]
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[[Category: Dhuyvetter, D]]
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[[Category: Fuchino K]]
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[[Category: Fuchino, K]]
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[[Category: Fujimoto K]]
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[[Category: Fujimoto, K]]
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[[Category: Fukushima T]]
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[[Category: Fukushima, T]]
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[[Category: Gijsen HJM]]
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[[Category: Gijsen, H J.M]]
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[[Category: Iso Y]]
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[[Category: Iso, Y]]
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[[Category: Ito H]]
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[[Category: Ito, H]]
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[[Category: Kanegawa N]]
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[[Category: Kanegawa, N]]
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[[Category: Kido Y]]
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[[Category: Kido, Y]]
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[[Category: Komano K]]
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[[Category: Komano, K]]
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[[Category: Kusakabe KI]]
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[[Category: Kusakabe, K I]]
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[[Category: Matsuoka E]]
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[[Category: Matsuoka, E]]
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[[Category: Nakahara K]]
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[[Category: Nakahara, K]]
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[[Category: Sakaguchi G]]
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[[Category: Sakaguchi, G]]
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[[Category: Suzuki S]]
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[[Category: Suzuki, S]]
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[[Category: Tadano G]]
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[[Category: Tadano, G]]
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[[Category: Teisman A]]
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[[Category: Teisman, A]]
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[[Category: Urmaliya V]]
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[[Category: Urmaliya, V]]
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[[Category: Yamamoto T]]
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[[Category: Yamamoto, T]]
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[[Category: Yamano Y]]
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[[Category: Yamano, Y]]
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[[Category: Yoshida S]]
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[[Category: Yoshida, S]]
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[[Category: Hydrolase]]
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Current revision

Crystal Structure of BACE1 in complex with N-{3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide

PDB ID 6jt3

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