8hke

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'''Unreleased structure'''
 
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The entry 8hke is ON HOLD until Paper Publication
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==dsRNA transporter==
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<StructureSection load='8hke' size='340' side='right'caption='[[8hke]], [[Resolution|resolution]] 3.71&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8hke]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HKE FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.71&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hke OCA], [https://pdbe.org/8hke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hke RCSB], [https://www.ebi.ac.uk/pdbsum/8hke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hke ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SID1_CAEEL SID1_CAEEL] Plays a role in RNA-mediated gene silencing by acting cell-autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent (PubMed:26067272). Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P.aeruginosa (PubMed:32908307).<ref>PMID:11834782</ref> <ref>PMID:12970568</ref> <ref>PMID:14738731</ref> <ref>PMID:17381285</ref> <ref>PMID:19155320</ref> <ref>PMID:19168628</ref> <ref>PMID:20512143</ref> <ref>PMID:21474576</ref> <ref>PMID:22178129</ref> <ref>PMID:22293577</ref> <ref>PMID:22902558</ref> <ref>PMID:26067272</ref> <ref>PMID:32908307</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jiang DH]]
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[[Category: Zhang JT]]

Revision as of 13:56, 29 November 2023

dsRNA transporter

PDB ID 8hke

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