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8pvb
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8pvb is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of GABAAR determined by cryoEM at 100 keV== | |
| - | + | <StructureSection load='8pvb' size='340' side='right'caption='[[8pvb]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8pvb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PVB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene>, <scene name='pdbligand=V8D:ethyl+1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate'>V8D</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pvb OCA], [https://pdbe.org/8pvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pvb RCSB], [https://www.ebi.ac.uk/pdbsum/8pvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pvb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Lama glama]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cannone G]] | ||
| + | [[Category: Chen S]] | ||
| + | [[Category: Dalby J]] | ||
| + | [[Category: Dickerson JL]] | ||
| + | [[Category: El-Gomati MM]] | ||
| + | [[Category: Gittins O]] | ||
| + | [[Category: Henderson R]] | ||
| + | [[Category: Hutchings KA]] | ||
| + | [[Category: Lee Y]] | ||
| + | [[Category: McMullan G]] | ||
| + | [[Category: Meffert M]] | ||
| + | [[Category: Mihaylov D]] | ||
| + | [[Category: Naydenova K]] | ||
| + | [[Category: Peet MJ]] | ||
| + | [[Category: Russo CJ]] | ||
| + | [[Category: Schulze-Briese C]] | ||
| + | [[Category: Sobhy M]] | ||
| + | [[Category: Wells T]] | ||
| + | [[Category: Wilson H]] | ||
| + | [[Category: Yamashita K]] | ||
Current revision
Structure of GABAAR determined by cryoEM at 100 keV
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Categories: Homo sapiens | Lama glama | Large Structures | Cannone G | Chen S | Dalby J | Dickerson JL | El-Gomati MM | Gittins O | Henderson R | Hutchings KA | Lee Y | McMullan G | Meffert M | Mihaylov D | Naydenova K | Peet MJ | Russo CJ | Schulze-Briese C | Sobhy M | Wells T | Wilson H | Yamashita K
